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Concept
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Enzyme Inhibitors
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Academic Article
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O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
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Academic Article
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Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
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Academic Article
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Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
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Academic Article
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Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
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Academic Article
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Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
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Academic Article
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O6-benzylguanine and its role in chemotherapy.
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Academic Article
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Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
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Academic Article
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In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
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Academic Article
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Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
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Academic Article
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Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
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Academic Article
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Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
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Academic Article
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Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.
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Academic Article
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Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
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Academic Article
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Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
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Academic Article
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Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
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Academic Article
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O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
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Academic Article
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A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
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Academic Article
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Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
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Academic Article
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Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
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Academic Article
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O6-benzylguanine-mediated enhancement of chemotherapy.
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