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One or more keywords matched the following properties of Liao, James
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overview Dr. Liao is the Harold H. Hines Jr. Professor of Medicine and Chief of Cardiology Section at the University of Chicago. He is also the Director of the Physician Scientist Development Program and Principal Investigator of the NIH T32 Cardiovascular Sciences Training Grant. His laboratory has made many important discoveries, which has helped elucidate signaling mechanisms in the vascular wall. Specifically, his laboratory explored molecular pathways which revealed how HMG-CoA reductase inhibitors (or statins) could exert cholesterol-independent or "pleiotropic" effects. This translational work provided a mechanistic basis for the benefit of statin therapy in stroke patients for which he received and was awarded the Cardiovascular Research Prize from the American Heart Association. His laboratory also identified, cloned, and characterized a novel cytochrome P450 epoxygenase, CYP2J2, and its products, epoxyeicosatrienoic acids (EETs), as endothelium-derived hyporpolarizing factors with anti-inflammatory and anti-ischemic properties. In addition, his work also led to the discovery of a novel, rapid, nongenomic effect of steroid hormone receptors. For his research accomplishments, Dr. Liao received the Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award from the American Heart Association and the Outstanding Investigator Award from the American Federation for Medical Research. He has served on numerous NIH study sections, advisory committees, and special emphasis panels.
One or more keywords matched the following items that are connected to Liao, James
Item TypeName
Concept Heart Function Tests
Concept Heart Septum
Concept Heart-Assist Devices
Concept Heart
Concept Heart Diseases
Concept Heart Failure
Concept Heart Septal Defects, Ventricular
Concept Heart Rate
Academic Article Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.
Academic Article Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.
Academic Article Increased Rho kinase activity in congestive heart failure.
Academic Article Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen.
Academic Article A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms.
Academic Article Mitohormesis: another pleiotropic effect of statins?
Academic Article Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells.
Academic Article Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.
Academic Article Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.
Academic Article Requirement of Rac1 in the development of cardiac hypertrophy.
Academic Article Novel aspects of the roles of Rac1 GTPase in the cardiovascular system.
Academic Article FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2.
Academic Article Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy.
Academic Article Rho Kinases and Cardiac Remodeling.
Academic Article Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding.
Academic Article Preservation of NO production by statins in the treatment of heart failure.
Academic Article Statin therapy for cardiac hypertrophy and heart failure.
Academic Article Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.
Academic Article Tumor necrosis factor-a levels and non-surgical bleeding in continuous-flow left ventricular assist devices.
Academic Article Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
Academic Article Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
Academic Article The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis.
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.
Academic Article Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
Academic Article Vascular Stiffening Mediated by Rho-Associated Coiled-Coil Containing Kinase Isoforms.
Grant Novel Signaling Pathways in Ischemic Stroke
Grant Activation of eNOS by Steroid Hormones
Grant Mechanisms Underlying Vascular Aging
Academic Article A Novel HIF-2a/ARNT Signaling Pathway Protects Against Microvascular Dysfunction and heart failure After Myocardial Infarction.
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