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Kron, Stephen J.
One or more keywords matched the following properties of Kron, Stephen J.
PropertyValue
keywords Senescence, Cell
keywords Checkpoints, Cell Cycle
overview The Kron laboratory is a diverse and collaborative group of cell biologists, geneticists, biochemists, chemists and computer scientists. Our current basic research and technology efforts include 1) defining roles for chromatin dynamics and cell cycle regulation in DNA damage checkpoint response and cellular senescence, 2) dissecting cross-talk between metabolism and DNA damage response, 3) developing novel molecular assays to interrogate cell signaling in cancer, and 4) implementing novel mass spectrometry approaches to enable quantitative proteomics. We also pursue translational projects directed at 1) discovering inhibitors of cellular response to DNA double strand breaks as an approach to radiosensitization, 2) examining DNA damage and repair in tissues and tumors, and 3) exploiting DNA damage responses to induce anti-tumor immune responses.
One or more keywords matched the following items that are connected to Kron, Stephen J.
Item TypeName
Concept Cell Fractionation
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Nucleus
Concept Carcinoma, Renal Cell
Concept Carcinoma, Non-Small-Cell Lung
Concept Cell Division
Concept Cell Extracts
Concept Cell-Free System
Concept Cell Adhesion
Concept Cell Cycle
Concept Cell Wall
Concept Dendritic Cells
Concept Cell Compartmentation
Concept Epithelial Cells
Concept Hematopoietic Stem Cells
Concept HeLa Cells
Concept Tumor Stem Cell Assay
Concept Tumor Cells, Cultured
Concept Cell Proliferation
Concept NIH 3T3 Cells
Concept Cell Growth Processes
Concept Cell Cycle Proteins
Concept Caco-2 Cells
Concept Platelet Endothelial Cell Adhesion Molecule-1
Concept HEK293 Cells
Concept Human Umbilical Vein Endothelial Cells
Concept Cell Death
Concept Cell Polarity
Concept HL-60 Cells
Concept K562 Cells
Concept Cell Cycle Checkpoints
Concept G1 Phase Cell Cycle Checkpoints
Concept Endothelial Cells
Concept Cell Line, Tumor
Concept Cell Size
Concept Cell Line
Concept Cell Nucleolus
Concept Cell Survival
Concept Cells, Cultured
Concept U937 Cells
Academic Article Budding yeast morphogenesis: signalling, cytoskeleton and cell cycle.
Academic Article Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.
Academic Article A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1-Trk2 potassium transporter.
Academic Article Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth.
Academic Article Role of oxidative phosphorylation in Bax toxicity.
Academic Article Sensing, signalling and integrating physical processes during Saccharomyces cerevisiae invasive and filamentous growth.
Academic Article NuA4 subunit Yng2 function in intra-S-phase DNA damage response.
Academic Article Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair.
Academic Article Cell cycle control of yeast filamentous growth.
Academic Article Digital time-lapse microscopy of yeast cell growth.
Academic Article Depression of Saccharomyces cerevisiae invasive growth on non-glucose carbon sources requires the Snf1 kinase.
Academic Article Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy.
Academic Article Mutations in the yeast cyclin-dependent kinase Cdc28 reveal a role in the spindle assembly checkpoint.
Academic Article Monitoring changes in the subcellular location of proteins in S. cerevisiae.
Academic Article Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism.
Academic Article Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.
Academic Article Protein-acrylamide copolymer hydrogels for array-based detection of tyrosine kinase activity from cell lysates.
Academic Article Asynchronous cell cycle and asymmetric vacuolar inheritance in true hyphae of Candida albicans.
Academic Article Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.
Academic Article Assaying Bcr-Abl kinase activity and inhibition in whole cell extracts by phosphorylation of substrates immobilized on agarose beads.
Academic Article CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage.
Academic Article Phosphoprotein profiling by PA-GeLC-MS/MS.
Academic Article Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites.
Academic Article Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide.
Academic Article Subtilisin cleavage of actin inhibits in vitro sliding movement of actin filaments over myosin.
Academic Article Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.
Academic Article Photocleavable peptide-conjugated magnetic beads for protein kinase assays by MALDI-TOF MS.
Academic Article Control of the yeast cell cycle with a photocleavable alpha-factor analogue.
Academic Article Cell treatment and lysis in 96-well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole-cell extracts.
Academic Article Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors.
Academic Article Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array.
Academic Article Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation.
Academic Article Non-catalytic function for ATR in the checkpoint response.
Academic Article Annotator: postprocessing software for generating function-based signatures from quantitative mass spectrometry.
Academic Article Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors.
Academic Article A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells.
Academic Article Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns.
Academic Article A pairwise chemical genetic screen identifies new inhibitors of glucose transport.
Academic Article Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae.
Academic Article Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy.
Academic Article Morphogenesis signaling components influence cell cycle regulation by cyclin dependent kinase.
Academic Article A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.
Academic Article Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.
Academic Article Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3.
Academic Article Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae.
Academic Article Yeast cell death during DNA damage arrest is independent of caspase or reactive oxygen species.
Academic Article Optimizing thiophosphorylation in the presence of competing phosphorylation with MALDI-TOF-MS detection.
Academic Article Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
Academic Article A solid-phase Bcr-Abl kinase assay in 96-well hydrogel plates.
Academic Article Peptide reporters of kinase activity in whole cell lysates.
Academic Article Activity assay of epidermal growth factor receptor tyrosine kinase inhibitors in triple-negative breast cancer cells using peptide-conjugated magnetic beads.
Academic Article Kinase activation in circulating cells: opportunities for biomarkers for diagnosis and therapeutic monitoring.
Academic Article CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
Academic Article DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast.
Academic Article The yin and yang of cyclin control by nutrients.
Academic Article Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase.
Academic Article c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.
Academic Article Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity.
Academic Article Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.
Academic Article Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.
Academic Article Lipid-derived reactive aldehydes link oxidative stress to cell senescence.
Academic Article Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers.
Academic Article Modulation of therapy-induced senescence by reactive lipid aldehydes.
Academic Article Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment.
Academic Article Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers.
Academic Article Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins.
Academic Article Three-Dimensional Analysis of the Human Pancreas.
Academic Article STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability.
Academic Article Radiation-enhanced delivery of plasmid DNA to tumors utilizing a novel PEI polyplex.
Academic Article Multiplex three-dimensional optical mapping of tumor immune microenvironment.
Academic Article A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.
Academic Article Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment.
Academic Article The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.
Academic Article A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic driver in lung cancer.
Academic Article The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.
Academic Article O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors.
Academic Article Targeted antibody and cytokine cancer immunotherapies through collagen affinity.
Academic Article A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence.
Academic Article Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.
Academic Article Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence.
Academic Article Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer.
Academic Article Immune profiles in primary squamous cell carcinoma of the head and neck.
Academic Article Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis.
Academic Article Targeted Covalent Inhibition of Telomerase.
Academic Article Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Academic Article Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.
Academic Article Nuclear Sphingosine-1-phosphate Lyase Generated ?2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells.
Academic Article Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response.
Academic Article Genomic studies controvert the existence of the CUX1 p75 isoform.
Academic Article Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization.
Academic Article Epidermal stratification requires retromer-mediated desmoglein-1 recycling.
Academic Article Far-red Fluorescent Senescence-associated ß-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry.
Academic Article Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells.
Concept A549 Cells
Concept MCF-7 Cells
Academic Article Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells.
Academic Article Protocol for examining the capability of senescent tumor cells to stimulate murine bone-marrow-derived dendritic cells by flow cytometry.
Search Criteria
  • Cell
  • Molecular Biology