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One or more keywords matched the following properties of Pinto, Jayant M.
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overview Dr. Pinto's research program has three major thematic goals: 1) To understand the effect of aging on sinonasal and sensory disorders 2) To determine how genetics, the environment, and social context (and their interaction) modulate susceptibility to these conditions 3) To use this information to develop and test novel treatments for these and other common conditions of the ear, nose, and throat He utilizes tools from the fields of demography, genetic epidemiology, genomics, public health and sociology to accomplish these goals. Dr. Pinto's research is funded by the National Institute on Aging and the National Institute of Allergy and Infectious Disease. Research Projects: Epidemiology of Presbyosmia (Age-Related Olfactory Decline) We are exploiting data from the National Social Life, Health, and Aging Project (NSHAP) (led by Linda Waite in Sociology), to study the demographic and other non-genetic factors that are associated with olfactory decline in aging. We have identified race as a key factor that is independently associated with olfactory function and demonstrated that anosmia predicts five year all cause mortality in US adults, providing some the first nationally representative data on this condition. We are also examining the rich array of health and social measures available in NSHAP, including state of the art biomeasures to determine underlying biological mechanisms and environmental determinants. Additional members of the Olfactory Research Group (the ORG) include Martha McClintock in Psychology and William Dale in Geriatric and Palliative Medicine, along with statisticians Kristin Wroblewski and Philip Schumm in Public Health Studies. Genetics of Presbyosmia ?We are employing genome wide association studies in a founder population to identify genetic variation that underlies age-related olfactory loss using quantitative trait loci mapping in collaboration with Carole Ober in Human Genetics. We published the first successful linkage study for an olfactory trait in humans and are pursuing other collaborations (David Bennett, Rush University) to identify genetic contributions to this important disorder. Genetics of Chronic Rhinosinusitis We are performing state of the art genetic, epigenetic, and genomic studies of CRS as part of the Chronic Rhinosinusitis Integrated Studies Program, a U19 award from the National Institute of Allergy and Infectious Disease in collaboration with Northwestern University (Robert Schleimer) and Johns Hopkins University/Geisinger Health System (Brian Schwartz). The project at The University of Chicago, in partnership with Carole Ober, focuses on genetic variation in pathogen response. Our project is the only National Institutes of Health-funded project on the genetics of this disorder. The Upper Airway Microbiome We have shown that the microbial ecology in the middle meatus of the sinuses is altered in allergic subjects, potentially predisposing to disease. We have several ongoing investigations into how the sinonasal microbiome predicts physiological changes in both the upper and lower airway, as well as factors that affect its composition and function. Collaborating on these projects are Robert Naclerio and Fuad Baroody in OHNS, along with Carole Ober and Yoav Gilad in Human Genetics. Rhinology Clinical Trials and Translational Research The Nasal Physiology Laboratory, a joint endeavor with Robert Naclerio and Fuad Baroody, runs ongoing clinical trials and translational studies of conditions such as allergic and non-allergic rhinitis, chronic rhinosinusitis, nasal polyposis, and other common conditions. Call 773-702-5889 for details on our current projects.
One or more keywords matched the following items that are connected to Pinto, Jayant M.
Item TypeName
Concept Cross-Sectional Studies
Concept Cohort Studies
Concept Urban Population
Concept Case-Control Studies
Concept Cross-Over Studies
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Retrospective Studies
Academic Article Lack of utility of postoperative chest radiograph in pediatric tracheotomy.
Academic Article Treatment of nasal inflammation decreases the ability of subjects with asthma to condition inspired air.
Academic Article Alpha-adrenoreceptor blockade with phenoxybenzamine does not affect the ability of the nose to condition air.
Academic Article Familial aggregation of nasal conditioning capacity.
Academic Article Effect of changing airway pressure on the ability of the human nose to warm and humidify air.
Academic Article Elucidating the mechanism underlying the ocular symptoms associated with allergic rhinitis.
Academic Article Long-term effects of hearing aids on word recognition scores.
Academic Article Otolaryngology (urban) legend: the more programs to which you apply, the better the chances of matching.
Academic Article Olfactory function in Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Racial disparities in olfactory loss among older adults in the United States.
Academic Article Sensory function: insights from Wave 2 of the National Social Life, Health, and Aging Project.
Academic Article Does airway surgery lower serum lipid levels in obstructive sleep apnea patients? A retrospective case review.
Academic Article Diagnostic algorithm for unilateral sinus disease: a 15-year retrospective review.
Academic Article Adequate continuous positive airway pressure therapy reduces mortality in Chinese patients with obstructive sleep apnea.
Academic Article The Rate of Age-Related Olfactory Decline Among the General Population of Older U.S. Adults.
Academic Article Genome-wide Meta-analysis on the Sense of Smell Among US Older Adults.
Academic Article Can upper airway surgery for OSA protect against cardiovascular sequelae via effects on coagulation?
Academic Article Olfactory Dysfunction in Older Adults is Associated with Feelings of Depression and Loneliness.
Academic Article A clinical trial of a microcrystalline cellulose topical nasal spray on the acute response to allergen challenge.
Academic Article Gender difference in Chinese adults with post-viral olfactory disorder:a hospital-based study.
Academic Article Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults.
Academic Article Chondrosarcoma--a roentgenographic and follow-up study.
Academic Article Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults.
Academic Article Sensory Dysfunction and Sexuality in the U.S. Population of Older Adults.
Academic Article Patient and surgeon factors explain variation in the frequency of frontal sinus surgery.
Academic Article A Retrospective Study to Compare the Use of the Mean Apnea-Hypopnea Duration and the Apnea-Hypopnea Index with Blood Oxygenation and Sleep Patterns in Patients with Obstructive Sleep Apnea Diagnosed by Polysomnography.
Academic Article Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults.
Academic Article Adjuvant radiation and survival following surgical resection of sinonasal melanoma.
Academic Article Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study.
Academic Article Olfactory dysfunction persists after smoking cessation and signals increased cardiovascular risk.
Academic Article Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop.
Academic Article Odor Sensitivity Versus Odor Identification in Older US Adults: Associations With Cognition, Age, Gender, and Race.
Academic Article Hearing Impairment and Loneliness in Older Adults in the United States.
Academic Article Identification of Viruses in Patients With Postviral Olfactory Dysfunction by Multiplex Reverse-Transcription Polymerase Chain Reaction.
Academic Article Self-Reported Versus Objectively Assessed Olfaction and Parkinson's Disease Risk.
Academic Article Olfactory Dysfunction Predicts the Development of Depression in Older US Adults.
Academic Article Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults.
Academic Article Olfaction Is Associated With Sexual Motivation and Satisfaction in Older Men and Women.
Academic Article Exposure to Particulate Matter Air Pollution and Anosmia.
Academic Article Long-Term Exposure to Particulate Matter Air Pollution and Chronic Rhinosinusitis in Nonallergic Patients.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article Assessment of Self-reported Sense of Smell, Objective Testing, and Associated Factors in Middle-aged and Older Women.
Academic Article Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Academic Article Rapid olfactory decline during aging predicts dementia and GMV loss in AD brain regions.
Academic Article Poor olfaction and pneumonia hospitalisation among community-dwelling older adults: a cohort study.
Academic Article Association of air pollution with olfactory identification performance of São Paulo residents: a cross-sectional study.
Concept Observational Studies as Topic
Academic Article Are rhinitis and Eustachian tube dysfunction associated in United States adolescents?
Academic Article Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms.
Academic Article Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases.
Academic Article The Role of Health Insurance Type and Clinic Visit on Hypertension Status Among Multiethnic Chicago Residents.
Academic Article Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.
Academic Article Sensory Health Among Older Adults in the United States: A Neighborhood Context Approach.
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  • Urban Population
  • Studies