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Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.

One or more keywords matched the following properties of Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.

Property	Value
has minor subject area list	Acrylamides; Aniline Compounds; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crizotinib; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Molecular Targeted Therapy; Mutation; Pyrazoles; Pyridines; Pyrimidines; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

Property

Value

has minor subject area list

Acrylamides; Aniline Compounds; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Crizotinib; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Molecular Targeted Therapy; Mutation; Pyrazoles; Pyridines; Pyrimidines; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

Search Criteria

G1 Phase Cell Cycle Checkpoints