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Mcnerney, Megan
One or more keywords matched the following properties of Mcnerney, Megan
PropertyValue
keywords Genomics
keywords Cancer
overview The McNerney lab studies the genomic changes in blood cancers with the goal of identifying therapeutic vulnerabilities. We focus on myeloid malignancies which are particularly difficult to treat. We apply a variety of functional genomics approaches and model systems to decipher changes in the cancer genome. Ongoing and available projects include studies of hematopoietic stem cell regulation, gene regulation during hematopoiesis, contiguous gene syndromes in cancer, and oncogenic signaling. Please visit our webpage for more information https://voices.uchicago.edu/mcnerneylab/
One or more keywords matched the following items that are connected to Mcnerney, Megan
Item TypeName
Concept Breast Neoplasms
Concept Neoplasms, Second Primary
Concept Mouth Neoplasms
Concept Neoplasms
Academic Article Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
Academic Article 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.
Academic Article Genetic pathways leading to therapy-related myeloid neoplasms.
Academic Article Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA.
Academic Article Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets.
Academic Article Widespread genetic epistasis among cancer genes.
Academic Article Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.
Academic Article Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Academic Article Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays.
Academic Article Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression.
Award or Honor Receipt “V” Foundation in Cancer Research Scholar Award
Award or Honor Receipt Evans Travel Award, FASEB Hematologic Malignancies Science Research Conference
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Award or Honor Receipt Cancer Research Foundation Young Investigator Award
Award or Honor Receipt American Cancer Society Research Scholar Award
Academic Article Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms.
Academic Article Loss of a 7q gene, CUX1, disrupts epigenetic-driven DNA repair and drives therapy-related myeloid neoplasms.
Academic Article Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Academic Article Genomic studies controvert the existence of the CUX1 p75 isoform.
Academic Article The significance of CUX1 and chromosome 7 in myeloid malignancies.
Academic Article Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
Concept Triple Negative Breast Neoplasms
Grant Next-Generation Sequencing of Therapy-Related Acute Myeloid Leukemia
Grant Determining the role of CUX1 in myeloid neoplasia
Academic Article Haploinsufficient Transcription Factors in Myeloid Neoplasms.
Search Criteria
  • Cancer
  • Genomics