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Aberrant RNA splicing and its functional consequences in cancer cells.
Academic Article
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RNA splicing is a primary link between genetic variation and disease.
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Staley, Jonathan P.
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Li, Yang
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Annotation-free quantification of RNA splicing using LeafCutter.
Academic Article
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RNA Splicing
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Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
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Piccirilli, Joseph A.
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A founder mutation in the Ashkenazi Jewish population affecting messenger RNA splicing of the CCM2 gene causes cerebral cavernous malformations.
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Zhang, Xiaochang
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Fica, Sebastian
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Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.
Academic Article
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U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.
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Cryo-EM structure of the spliceosome immediately after branching.
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Structure of a spliceosome remodelled for exon ligation.
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