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London, Sarah

One or more keywords matched the following properties of London, Sarah

Property	Value
keywords	development, learning & memory, epigenetics, genomics, molecular signaling, critical period
overview	We still don’t know what properties of the brain promote and limit the ability to learn although behaviorally, we observe individual, sex, and age differences in the long-term effects of experience. Memory formation requires that two major levels of neurobiology are coordinated 1) the presence of a subset of cells, or "ensemble," that are capable of participating in memory storage and 2) the triggering of appropriate molecular and genomic changes in response to experience. The challenges of placing molecular underpinnings of neural plasticity within cell populations that are engaged in memory formation are compounded by the need to behaviorally link cellular and molecular brain properties to the ability to learn. In the London Lab, we take advantage of a model system that has a Critical Period for sensory learning, the zebra finch songbird, to discover how epigenetic mechanisms, genomic regulation, molecular signaling, and cell subtypes contribute to the ability to learn complex natural behaviors. Because Critical Periods define restricted phases in development when an experience is optimally encoded in ways that have long-term consequences on brain function and behavioral patterns, we can meaningfully link neural properties before, during, and after the Critical Period to behavioral outcomes.

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keywords

development, learning & memory, epigenetics, genomics, molecular signaling, critical period

overview

We still don’t know what properties of the brain promote and limit the ability to learn although behaviorally, we observe individual, sex, and age differences in the long-term effects of experience. Memory formation requires that two major levels of neurobiology are coordinated 1) the presence of a subset of cells, or "ensemble," that are capable of participating in memory storage and 2) the triggering of appropriate molecular and genomic changes in response to experience. The challenges of placing molecular underpinnings of neural plasticity within cell populations that are engaged in memory formation are compounded by the need to behaviorally link cellular and molecular brain properties to the ability to learn. In the London Lab, we take advantage of a model system that has a Critical Period for sensory learning, the zebra finch songbird, to discover how epigenetic mechanisms, genomic regulation, molecular signaling, and cell subtypes contribute to the ability to learn complex natural behaviors. Because Critical Periods define restricted phases in development when an experience is optimally encoded in ways that have long-term consequences on brain function and behavioral patterns, we can meaningfully link neural properties before, during, and after the Critical Period to behavioral outcomes.

One or more keywords matched the following items that are connected to London, Sarah

Item Type	Name
Concept	Verbal Learning
Concept	Learning
Academic Article	Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.
Academic Article	Developmental shifts in gene expression in the auditory forebrain during the sensitive period for song learning.
Academic Article	Functional identification of sensory mechanisms required for developmental song learning.
Academic Article	Developmental song learning as a model to understand neural mechanisms that limit and promote the ability to learn.
Academic Article	Bidirectional manipulation of mTOR signaling disrupts socially mediated vocal learning in juvenile songbirds.
Academic Article	Epigenetic regulation of transcriptional plasticity associated with developmental song learning.
Academic Article	The zebra finch neuropeptidome: prediction, detection and expression.
Academic Article	An Acoustic Password Enhances Auditory Learning in Juvenile Brood Parasitic Cowbirds.
Academic Article	Inhibitory cell populations depend on age, sex, and prior experience across a neural network for Critical Period learning.
Academic Article	Experience selectively alters functional connectivity within a neural network to predict learned behavior in juvenile songbirds.
Concept	Social Learning
Grant	Mechanisms of age- and experience-dependent neural plasticity and behavior
Grant	The molecular basis for developmental sensory learning
Academic Article	Listen and learn.
Grant	At the right time and place ? identifying epigenetic and molecular determinants of a developmental learning window

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Learning