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Directed Molecular Evolution
Coevolution-based inference of amino acid interactions underlying protein function.
Deconstruction of the Ras switching cycle through saturation mutagenesis.
Natural-like function in artificial WW domains.
Origins of Allostery and Evolvability in Proteins: A Case Study.
Evolutionary information for specifying a protein fold.
An evolutionary hotspot defines functional differences between CRYPTOCHROMES.
Evolvability as a function of purifying selection in TEM-1 ß-lactamase.
Evolution-Based Functional Decomposition of Proteins.
Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
Evolution-based design of proteins.
Protein sectors: evolutionary units of three-dimensional structure.
Structural determinants of allosteric ligand activation in RXR heterodimers.
Evolutionarily conserved networks of residues mediate allosteric communication in proteins.
The spatial architecture of protein function and adaptation.
Allosteric determinants in guanine nucleotide-binding proteins.
Hot spots for allosteric regulation on protein surfaces.
Putting Evolution to Work.
Learning the pattern of epistasis linking genotype and phenotype in a protein.
An evolution-based model for designing chorismate mutase enzymes.
RNA sectors and allosteric function within the ribosome.