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One or more keywords matched the following properties of Zhang, Xiaochang
keywords Brain development and disorders
overview How our brain is developed and evolved remains a major question, and abnormal development of the human brain can cause autism, epilepsy and intellectual disability. We study fundamental mechanisms of brain development and disorders. Our current research includes: mechanisms of cell type specification in mammalian brains, genetics of neurodevelopmental disorders, and roles of mRNA isoforms in neural development and diseases. We develop and apply single-cell approaches, animal models, and functional genomics to address these questions.
One or more keywords matched the following items that are connected to Zhang, Xiaochang
Item TypeName
Concept Brain Diseases
Concept Autistic Disorder
Concept Brain
Concept Chromosome Deletion
Concept Microcephaly
Concept Intellectual Disability
Concept Starvation
Concept Malformations of Cortical Development
Concept Lissencephaly
Concept Agenesis of Corpus Callosum
Concept Periventricular Nodular Heterotopia
Concept Chromosome Disorders
Concept Classical Lissencephalies and Subcortical Band Heterotopias
Concept Hydrocephalus
Concept Seizures
Academic Article SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
Academic Article Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
Academic Article Somatic mutations in cerebral cortical malformations.
Academic Article Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.
Grant Cell Type-specific Alternative Splicing Controls Cerebral Cortical Development
Academic Article Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival.
Grant Single cell detection of dynamic protein-RNA interaction
Academic Article Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.
Academic Article Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain.
Search Criteria
  • Brain
  • development
  • disorders