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overview Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

One or more keywords matched the following items that are connected to Bianco, Antonio

Item TypeName
Concept Amino Acids
Concept Bile Acids and Salts
Concept Amino Acid Sequence
Concept Basal Metabolism
Concept Base Sequence
Concept Caffeic Acids
Concept Citric Acid Cycle
Concept Coumaric Acids
Concept Glial Fibrillary Acidic Protein
Concept Fatty Acids
Concept Energy Metabolism
Concept Metabolism
Concept Pyrrolidonecarboxylic Acid
Concept Iopanoic Acid
Concept Sequence Homology, Amino Acid
Concept Taurochenodeoxycholic Acid
Concept Nucleic Acid Precursors
Concept Palmitic Acid
Concept Cholic Acid
Concept Amino Acid Substitution
Concept Lactic Acid
Concept Base Pairing
Concept Fatty Acid-Binding Proteins
Concept Lipid Metabolism
Academic Article Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Academic Article The History and Future of Treatment of Hypothyroidism.
Academic Article Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Academic Article Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
Academic Article Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes.
Academic Article Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.
Academic Article Adaptive activation of thyroid hormone and energy expenditure.
Academic Article Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.
Academic Article The thyroid hormone-inactivating deiodinase functions as a homodimer.
Academic Article The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
Academic Article Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat.
Academic Article A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
Academic Article Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
Academic Article LXRs regulate the balance between fat storage and oxidation.
Academic Article Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle.
Academic Article Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Academic Article Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.
Academic Article Thyroid hormone signaling in energy homeostasis and energy metabolism.
Academic Article Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
Academic Article The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Academic Article Metabolic effects of thyroid hormones-beyond traditional prospects.
Academic Article Deiodinases: implications of the local control of thyroid hormone action.
Academic Article betaAR signaling required for diet-induced thermogenesis and obesity resistance.
Academic Article Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Academic Article Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Academic Article Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.
Academic Article Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
Academic Article Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup.
Academic Article Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.
Academic Article The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
Academic Article Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice.
Academic Article Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Academic Article The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
Academic Article Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
Academic Article The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Academic Article Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Academic Article Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
Academic Article A TRbeta-selective agonist confers resistance to diet-induced obesity.
Academic Article Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Academic Article [Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment].
Academic Article The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Academic Article ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice.
Academic Article Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
Academic Article Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.
Academic Article Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold.
Academic Article Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Academic Article Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
Academic Article S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis.
Academic Article Mice lacking brain-type creatine kinase activity show defective thermoregulation.
Academic Article Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Academic Article Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
Academic Article Cracking the code for thyroid hormone signaling.
Academic Article Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.
Academic Article Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Academic Article Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Academic Article Human type 1 Iodothyronine deiodinase (DIO1) mutations cause abnormal thyroid hormone metabolism.

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