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overview Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).
One or more keywords matched the following items that are connected to Bianco, Antonio
Item TypeName
Concept Basal Metabolism
Concept Energy Metabolism
Concept Metabolism
Concept Lipid Metabolism
Academic Article Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Academic Article The History and Future of Treatment of Hypothyroidism.
Academic Article Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
Academic Article Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.
Academic Article Adaptive activation of thyroid hormone and energy expenditure.
Academic Article The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
Academic Article Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
Academic Article LXRs regulate the balance between fat storage and oxidation.
Academic Article Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.
Academic Article Thyroid hormone signaling in energy homeostasis and energy metabolism.
Academic Article Metabolic effects of thyroid hormones-beyond traditional prospects.
Academic Article Deiodinases: implications of the local control of thyroid hormone action.
Academic Article betaAR signaling required for diet-induced thermogenesis and obesity resistance.
Academic Article Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Academic Article Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.
Academic Article Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
Academic Article Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.
Academic Article Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Academic Article The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
Academic Article The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Academic Article A TRbeta-selective agonist confers resistance to diet-induced obesity.
Academic Article Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Academic Article ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice.
Academic Article Mice lacking brain-type creatine kinase activity show defective thermoregulation.
Academic Article Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
Academic Article Cracking the code for thyroid hormone signaling.
Academic Article Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Academic Article Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Academic Article Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
Academic Article Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice.
Grant Thyroid-adrenergic synergism and adaptive thermogenesis
Grant Selenodeidinase Processing by the Proteasome System
Grant Metabolic and xenobiotic control of thyroid hormone metabolism
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