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One or more keywords matched the following properties of Pincus, David
overview David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation. David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models. Key project areas: 1) Quantitative cell biology of the heat shock response 2) Single-cell transcriptomics in complex stress environments
One or more keywords matched the following items that are connected to Pincus, David
Item TypeName
Concept Heat-Shock Response
Academic Article Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Academic Article Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.
Academic Article tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.
Academic Article Size doesn't matter in the heat shock response.
Academic Article Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock.
Academic Article Regulation of Hsf1 and the Heat Shock Response.
Academic Article Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Academic Article Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Academic Article Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.
Grant Regulatory Dynamics of the Proteostasis Network
Grant Quantitative approaches to reveal the homeostatic control mechanisms of stress re
Academic Article Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response.
Academic Article Feedback control of the heat shock response by spatiotemporal regulation of Hsp70.
Academic Article The Heat Shock Response as a Condensate Cascade.
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  • Heat Shock Response