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One or more keywords matched the following properties of Muir, Alexander
keywords Metabolism
keywords Cancer Metabolism
overview Our group is interested in understanding the metabolic adaptations that allow cancer cells to grow and proliferate, causing tumor growth. To understand how cancer cell metabolism works to fuel tumor growth, we use metabolomics techniques to catalog what nutrients are in the microenvironment of tumors. This provides us with a "menu" of nutrients that cancer cells could potentially metabolize to fuel their growth. Once we know the "menu" for different tumor types, we then use a variety of experimental tools from metabolomics to CRISPR gene editing to determine which nutrients cancer cells actually consume from the "menu", and which metabolic pathways process these nutrients. From these experiments, we are delineating the biochemical underpinnings of cancer cell growth.
One or more keywords matched the following items that are connected to Muir, Alexander
Item TypeName
Concept Neoplasm Transplantation
Concept Pancreatic Neoplasms
Concept Lung Neoplasms
Concept Drug Resistance, Neoplasm
Concept Tumor Cells, Cultured
Concept Tumor Microenvironment
Concept Cell Line, Tumor
Concept Lipid Metabolism
Concept Neoplasms
Academic Article Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.
Academic Article Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies.
Academic Article Altered exocrine function can drive adipose wasting in early pancreatic cancer.
Academic Article The nutrient environment affects therapy.
Academic Article Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.
Academic Article Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
Academic Article Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
Academic Article Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Academic Article Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression.
Academic Article Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth.
Academic Article Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS.
Academic Article Cell-programmed nutrient partitioning in the tumour microenvironment.
Academic Article Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1.
Academic Article Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Academic Article The requirement for mitochondrial respiration in cancer varies with disease stage.
Academic Article Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Academic Article Uridine-derived ribose fuels glucose-restricted pancreatic cancer.
Academic Article Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis.
Academic Article Tumor interstitial fluid analysis enables the study of microenvironment-cell interactions in cancers.
Academic Article Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Academic Article Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Academic Article Mitochondrial One-Carbon Metabolism is Required for TGF-ß-Induced Glycine Synthesis and Collagen Protein Production.
Academic Article Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
Academic Article Generation and ex vivo culture of murine and human pancreatic ductal adenocarcinoma tissue slice explants.
Search Criteria
  • Tumor
  • metabolism