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One or more keywords matched the following properties of Spitz, Francois
keywords Developmental Disorders
overview Our group is interested in understanding how the architecture of the genome contributes to the specificity and robustness of the gene expression programs that govern embryonic development and cell differentiation. Vertebrate genomes contain hundreds of thousands of regulatory sequences that can influence the expression of genes sometimes located hundreds of kilobases away. Our main goal is to understand how the folding of the genome in specific domains and dynamic structures contributes to transform such a dispersed information into highly specific regulatory ensembles. We study as well how perturbations of these processes, notably due to chromosomal rearrangements, could lead to developmental or oncogenic pathologies, but may have also participated to animal evolution.
One or more keywords matched the following items that are connected to Spitz, Francois
Item TypeName
Concept Adenocarcinoma
Concept Congenital Abnormalities
Concept Breast Neoplasms
Concept Carcinoma
Concept Cleft Lip
Concept Foot Deformities, Congenital
Concept Cleft Palate
Concept Disease
Concept Leukemia
Concept Chromosome Inversion
Concept Neovascularization, Pathologic
Concept Obesity
Concept Liver Neoplasms
Concept Syndrome
Concept Lymphatic Metastasis
Concept Leukemia, Myeloid, Acute
Concept Melanoma
Concept Limb Deformities, Congenital
Concept Neoplasm Recurrence, Local
Concept Sequence Deletion
Concept Gene Expression Regulation, Developmental
Concept Peritoneal Neoplasms
Concept Genetic Association Studies
Concept Genetic Diseases, Inborn
Concept Sarcoma
Concept Skin Neoplasms
Concept Genes, Developmental
Concept Colorectal Neoplasms
Concept Developmental Biology
Concept Chromosome Duplication
Concept Bone Diseases, Developmental
Concept Disease Models, Animal
Concept Hand Deformities, Congenital
Concept Mutagenesis, Insertional
Academic Article A regulatory archipelago controls Hox genes transcription in digits.
Academic Article Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression.
Academic Article Genomics and development: Taking developmental biology to new heights.
Academic Article An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.
Academic Article A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes.
Academic Article Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor.
Academic Article A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects.
Academic Article Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.
Academic Article Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.
Academic Article A switch between topological domains underlies HoxD genes collinearity in mouse limbs.
Academic Article A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.
Academic Article Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations.
Academic Article Developmental regulation of the aldolase A muscle-specific promoter during in vivo muscle maturation is controlled by a nuclear receptor binding element.
Academic Article Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences.
Academic Article Developmental biology: reproduction in clusters.
Academic Article Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq.
Academic Article Gene regulation during development in the light of topologically associating domains.
Academic Article The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances.
Academic Article From remote enhancers to gene regulation: charting the genome's regulatory landscapes.
Academic Article Uncoupling time and space in the collinear regulation of Hox genes.
Academic Article Transgenic analysis of Hoxd gene regulation during digit development.
Academic Article Transcription factors: from enhancer binding to developmental control.
Academic Article Global control regions and regulatory landscapes in vertebrate development and evolution.
Search Criteria
  • Developmental
  • Disorders