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overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Concept Adenovirus Infections, Human
Concept Bacterial Infections
Concept Borrelia Infections
Concept Clostridium Infections
Concept Cross Infection
Concept Cytomegalovirus Infections
Concept Enterobacteriaceae Infections
Concept Escherichia coli Infections
Concept Nematode Infections
Concept Opportunistic Infections
Concept Streptococcal Infections
Concept Protozoan Infections
Concept Respiratory Tract Infections
Concept Klebsiella Infections
Concept Staphylococcal Infections
Concept Bacteroidaceae Infections
Concept Gram-Positive Bacterial Infections
Concept Gram-Negative Bacterial Infections
Concept Paramyxoviridae Infections
Concept Caliciviridae Infections
Concept Asymptomatic Infections
Concept HIV Infections
Concept Urinary Tract Infections
Concept Pneumocystis Infections
Concept Infection Control
Concept Epstein-Barr Virus Infections
Academic Article Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae.
Academic Article Early programming of T cell populations responding to bacterial infection.
Academic Article Prevention of peritransplantation viridans streptococcal bacteremia with early vancomycin administration: a single-center observational cohort study.
Academic Article Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection.
Academic Article Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele.
Academic Article Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Academic Article Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.
Academic Article Cuffed and exposed--perp-walking bradyrhizobium.
Academic Article Quantitative studies of CD8+ T-cell responses during microbial infection.
Academic Article MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.
Academic Article Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.
Academic Article T lymphocyte dynamics during Listeria monocytogenes infection.
Academic Article The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Academic Article Innate immune signaling in defense against intestinal microbes.
Academic Article H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses.
Academic Article T cell responses to bacterial infection.
Academic Article Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Academic Article Enlisting commensal microbes to resist antibiotic-resistant pathogens.
Academic Article Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.
Academic Article Monocytes and infection: modulator, messenger and effector.
Academic Article Monocyte-mediated immune defense against murine Listeria monocytogenes infection.
Academic Article Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence.
Academic Article Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?
Academic Article Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Academic Article Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection.
Academic Article Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
Academic Article Animal model for infection with Listeria monocytogenes.
Academic Article Commensal bacteria mediated defenses against pathogens.
Academic Article Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
Academic Article Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Academic Article CD8 T cell responses to infectious pathogens.
Academic Article Variable immunodominance hierarchies for H2-M3-restricted N-formyl peptides following bacterial infection.
Academic Article Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.
Academic Article Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients.
Academic Article Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study.
Academic Article The CD40-CD154 system in anti-infective host defense.
Academic Article Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir.
Academic Article TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article T cell affinity maturation by selective expansion during infection.
Academic Article Immune responses to Aspergillus fumigatus infections.
Academic Article Distinct Contributions of Neutrophils and CCR2+ Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains.
Academic Article Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.
Academic Article Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.
Academic Article Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case-controlled study.
Academic Article The role of CD1-restricted T cells in infectious diseases.
Academic Article The intestinal microbiota and susceptibility to infection in immunocompromised patients.
Academic Article CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis.
Academic Article Microbiome mediation of infections in the cancer setting.
Academic Article CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
Academic Article Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
Academic Article Monocyte recruitment during infection and inflammation.
Academic Article Role of intestinal microbiota in transplantation outcomes.
Academic Article MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article Tipping the balance in favor of protective immunity during influenza virus infection.
Academic Article Commensal microbes provide first line defense against Listeria monocytogenes infection.
Academic Article Coordinate regulation of complex T cell populations responding to bacterial infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article Breakthrough trichosporonosis in a bone marrow transplant recipient receiving caspofungin acetate.
Academic Article Noncompetitive expansion of cytotoxic T lymphocytes specific for different antigens during bacterial infection.
Academic Article Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.
Academic Article Antigen presentation in the immune response to infectious diseases.
Academic Article Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus.
Academic Article Selective expansion of the monocytic lineage directed by bacterial infection.
Academic Article Clinical characterization of human metapneumovirus infection among patients with cancer.
Academic Article Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article Cell-mediated immunity: the role of bacterial protein secretion.
Academic Article Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections.
Academic Article Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Academic Article A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection.
Academic Article Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation.
Academic Article Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Academic Article Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.
Academic Article MHC class Jb-restricted cell responses to Listeria monocytogenes infection.
Academic Article Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.
Academic Article 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients.
Academic Article Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
Academic Article Transmission of Clostridium difficile During Hospitalization for Allogeneic Stem Cell Transplant.
Academic Article Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens.
Academic Article Intestinal and splenic T cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes.
Academic Article TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Academic Article Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization.
Academic Article Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Academic Article Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article TLR polymorphisms and the risk of invasive fungal infections.
Academic Article A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Academic Article Editorial overview.
Academic Article Monocyte-mediated defense against microbial pathogens.
Academic Article Coordinating innate immune cells to optimize microbial killing.
Academic Article Dynamic imaging of the effector immune response to listeria infection in vivo.
Academic Article Regulation of innate and adaptive immunity by the commensal microbiota.
Academic Article Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination.
Academic Article Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection.
Academic Article Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections.
Academic Article Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.
Academic Article Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.
Academic Article Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.
Academic Article Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients.
Academic Article Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study.
Academic Article Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.
Academic Article Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV.
Academic Article Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine.
Academic Article Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria.
Academic Article Outbreaks of Typhlocolitis Caused by Hypervirulent Group ST1 Clostridioides difficile in Highly Immunocompromised Strains of Mice.
Academic Article Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection.
Academic Article TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
Academic Article A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains.
Grant Innate immune defense against clostridium Difficile Infection
Grant Characterization of Aspergillus fumigatus specific CD4 T cell responses.
Grant CC-chemokines in Listeria infection.
Grant Innate Immune Responses to Microbial Flora
Grant Research Training in Infectious Diseases
Grant CD4 T Cell Responses to M. Tuberculosis Infection
Grant Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant Inflammation and T cell immunity to Listeria
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  • Infections