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Pamer, Eric

One or more keywords matched the following properties of Pamer, Eric

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overview	Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.

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overview

Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.

One or more keywords matched the following items that are connected to Pamer, Eric

Item Type	Name
Concept	Adenovirus Infections, Human
Concept	Bacterial Infections
Concept	Borrelia Infections
Concept	Clostridium Infections
Concept	Cross Infection
Concept	Cytomegalovirus Infections
Concept	Enterobacteriaceae Infections
Concept	Escherichia coli Infections
Concept	Nematode Infections
Concept	Opportunistic Infections
Concept	Streptococcal Infections
Concept	Protozoan Infections
Concept	Respiratory Tract Infections
Concept	Klebsiella Infections
Concept	Staphylococcal Infections
Concept	Bacteroidaceae Infections
Concept	Gram-Positive Bacterial Infections
Concept	Gram-Negative Bacterial Infections
Concept	Paramyxoviridae Infections
Concept	Caliciviridae Infections
Concept	Asymptomatic Infections
Concept	HIV Infections
Concept	Urinary Tract Infections
Concept	Pneumocystis Infections
Concept	Infection Control
Concept	Epstein-Barr Virus Infections
Academic Article	Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae.
Academic Article	Early programming of T cell populations responding to bacterial infection.
Academic Article	Prevention of peritransplantation viridans streptococcal bacteremia with early vancomycin administration: a single-center observational cohort study.
Academic Article	Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection.
Academic Article	Rapid expansion of cytomegalovirus-specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele.
Academic Article	Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Academic Article	Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.
Academic Article	Cuffed and exposed--perp-walking bradyrhizobium.
Academic Article	Quantitative studies of CD8+ T-cell responses during microbial infection.
Academic Article	MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.
Academic Article	Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.
Academic Article	T lymphocyte dynamics during Listeria monocytogenes infection.
Academic Article	The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Academic Article	Innate immune signaling in defense against intestinal microbes.
Academic Article	H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses.
Academic Article	T cell responses to bacterial infection.
Academic Article	Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Academic Article	Enlisting commensal microbes to resist antibiotic-resistant pathogens.
Academic Article	Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.
Academic Article	Monocytes and infection: modulator, messenger and effector.
Academic Article	Monocyte-mediated immune defense against murine Listeria monocytogenes infection.
Academic Article	Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence.
Academic Article	Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?
Academic Article	Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Academic Article	Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection.
Academic Article	Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
Academic Article	Animal model for infection with Listeria monocytogenes.
Academic Article	Commensal bacteria mediated defenses against pathogens.
Academic Article	Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
Academic Article	Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Academic Article	CD8 T cell responses to infectious pathogens.
Academic Article	Variable immunodominance hierarchies for H2-M3-restricted N-formyl peptides following bacterial infection.
Academic Article	Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.
Academic Article	Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article	Pre- and post-engraftment bloodstream infection rates and associated mortality in allogeneic hematopoietic stem cell transplant recipients.
Academic Article	Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study.
Academic Article	The CD40-CD154 system in anti-infective host defense.
Academic Article	Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir.
Academic Article	TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article	T cell affinity maturation by selective expansion during infection.
Academic Article	Immune responses to Aspergillus fumigatus infections.
Academic Article	Distinct Contributions of Neutrophils and CCR2+ Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains.
Academic Article	Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.
Academic Article	Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.
Academic Article	Risk factors for late Staphylococcus aureus bacteremia after allogeneic hematopoietic stem cell transplantation: a single-institution, nested case-controlled study.
Academic Article	The role of CD1-restricted T cells in infectious diseases.
Academic Article	The intestinal microbiota and susceptibility to infection in immunocompromised patients.
Academic Article	CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis.
Academic Article	Microbiome mediation of infections in the cancer setting.
Academic Article	CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
Academic Article	Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
Academic Article	Monocyte recruitment during infection and inflammation.
Academic Article	Role of intestinal microbiota in transplantation outcomes.
Academic Article	MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article	Tipping the balance in favor of protective immunity during influenza virus infection.
Academic Article	Commensal microbes provide first line defense against Listeria monocytogenes infection.
Academic Article	Coordinate regulation of complex T cell populations responding to bacterial infection.
Academic Article	Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article	Breakthrough trichosporonosis in a bone marrow transplant recipient receiving caspofungin acetate.
Academic Article	Noncompetitive expansion of cytotoxic T lymphocytes specific for different antigens during bacterial infection.
Academic Article	Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.
Academic Article	Antigen presentation in the immune response to infectious diseases.
Academic Article	Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus.
Academic Article	Selective expansion of the monocytic lineage directed by bacterial infection.
Academic Article	Clinical characterization of human metapneumovirus infection among patients with cancer.
Academic Article	Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article	Cell-mediated immunity: the role of bacterial protein secretion.
Academic Article	Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections.
Academic Article	Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Academic Article	A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection.
Academic Article	Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article	Early Clostridium difficile infection during allogeneic hematopoietic stem cell transplantation.
Academic Article	Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Academic Article	Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.
Academic Article	MHC class Jb-restricted cell responses to Listeria monocytogenes infection.
Academic Article	Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.
Academic Article	2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients.
Academic Article	Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article	Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
Academic Article	Transmission of Clostridium difficile During Hospitalization for Allogeneic Stem Cell Transplant.
Academic Article	Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens.
Academic Article	Intestinal and splenic T cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes.
Academic Article	TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Academic Article	Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization.
Academic Article	Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Academic Article	Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article	TLR polymorphisms and the risk of invasive fungal infections.
Academic Article	A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Academic Article	Editorial overview.
Academic Article	Monocyte-mediated defense against microbial pathogens.
Academic Article	Coordinating innate immune cells to optimize microbial killing.
Academic Article	Dynamic imaging of the effector immune response to listeria infection in vivo.
Academic Article	Regulation of innate and adaptive immunity by the commensal microbiota.
Academic Article	Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination.
Academic Article	Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection.
Academic Article	Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections.
Academic Article	Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.
Academic Article	Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.
Academic Article	Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.
Academic Article	Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients.
Academic Article	Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study.
Academic Article	Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.
Academic Article	Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV.
Academic Article	Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine.
Academic Article	Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria.
Academic Article	Outbreaks of Typhlocolitis Caused by Hypervirulent Group ST1 Clostridioides difficile in Highly Immunocompromised Strains of Mice.
Academic Article	Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection.
Academic Article	TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
Academic Article	A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains.
Grant	CHARACTERIZATION OF A TRYPANSOMA BRUCEI PROTEASE
Grant	Innate immune defense against clostridium Difficile Infection
Grant	Characterization of Aspergillus fumigatus specific CD4 T cell responses.
Grant	CC-chemokines in Listeria infection.
Grant	Innate Immune Responses to Microbial Flora
Grant	Research Training in Infectious Diseases
Grant	H2-M3 RESTRICTED T CELL RESPONSES
Grant	CD4 T Cell Responses to M. Tuberculosis Infection
Grant	Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant	CYTOTOXIC T LYMPHOCYTE RESPONSE TO BACTERIAL INFECTION
Grant	Inflammation and T cell immunity to Listeria
Academic Article	Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.
Academic Article	Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection.
Academic Article	Intestinal carbapenem-resistant Klebsiella pneumoniae undergoes complex transcriptional reprogramming following immune activation.

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Infections