The University of Chicago Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Pamer, Eric
keywords Microbiome
keywords Microbiota
overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Academic Article Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Academic Article Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation.
Academic Article Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice.
Academic Article Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota.
Academic Article Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Academic Article Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant.
Academic Article The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Academic Article Fecal microbiota transplantation: effectiveness, complexities, and lingering concerns.
Academic Article From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease.
Academic Article Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Academic Article Antibiotics, microbiota, and immune defense.
Academic Article Gut Microbiota Predict Pulmonary Infiltrates after Allogeneic Hematopoietic Cell Transplantation.
Academic Article Microbiota-mediated inflammation and antimicrobial defense in the intestine.
Academic Article Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Academic Article Role of the commensal microbiota in normal and pathogenic host immune responses.
Academic Article IMMUNOTHERAPY. Could microbial therapy boost cancer immunotherapy?
Academic Article Gut microbiota dysbiosis and diarrhea in kidney transplant recipients.
Academic Article Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.
Academic Article The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study.
Academic Article Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity.
Academic Article Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.
Academic Article Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition.
Academic Article Enterococci and Their Interactions with the Intestinal Microbiome.
Academic Article The effects of amine-modified single-walled carbon nanotubes on the mouse microbiota.
Academic Article Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.
Academic Article Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.
Academic Article Microbiota-mediated colonization resistance against intestinal pathogens.
Academic Article Clostridium difficile colitis: pathogenesis and host defence.
Academic Article The intestinal microbiota and susceptibility to infection in immunocompromised patients.
Academic Article Microbiome mediation of infections in the cancer setting.
Academic Article Commensal microbiota affects ischemic stroke outcome by regulating intestinal ?d T cells.
Academic Article Gut microbial community structure and complications after kidney transplantation: a pilot study.
Academic Article The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.
Academic Article Role of intestinal microbiota in transplantation outcomes.
Academic Article Commensal microbes provide first line defense against Listeria monocytogenes infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.
Academic Article Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.
Academic Article Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections.
Academic Article Microbial Tuning of the Mammalian Immune System.
Academic Article Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease.
Academic Article Protective Factors in the Intestinal Microbiome Against Clostridium difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation.
Academic Article Gut microbiota and tacrolimus dosing in kidney transplantation.
Academic Article Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens.
Academic Article Short- and long-term effects of oral vancomycin on the human intestinal microbiota.
Academic Article Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization.
Academic Article Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.
Academic Article Regulation of innate and adaptive immunity by the commensal microbiota.
Academic Article Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections.
Academic Article Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.
Academic Article Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Academic Article Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.
Academic Article Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus.
Academic Article Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients.
Academic Article Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study.
Academic Article Lactose drives Enterococcus expansion to promote graft-versus-host disease.
Academic Article Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.
Academic Article Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria.
Academic Article Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.
Academic Article The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD.
Academic Article Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.
Academic Article Enhancing mucosal immunity by transient microbiota depletion.
Academic Article Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study.
Academic Article Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation.
Academic Article Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients.
Academic Article Author Correction: Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients.
Academic Article Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation.
Academic Article Microbiome-based therapeutics.
Academic Article Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.
Academic Article A compilation of fecal microbiome shotgun metagenomics from hematopoietic cell transplantation patients.
Academic Article Translating Microbiome Research From and To the Clinic.
Academic Article Metagenomic and bile acid metabolomic analysis of fecal microbiota transplantation for recurrent Clostridiodes difficile and/or inflammatory bowel diseases.
Academic Article Author Correction: Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy.
Academic Article Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.
Concept Gastrointestinal Microbiome
Concept Fecal Microbiota Transplantation
Grant Innate immune defense against clostridium Difficile Infection
Grant Innate Immune Responses to Microbial Flora
Grant Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant A Proposal for a Microbiome Center Conference
Academic Article Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions.
Academic Article High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients.
Academic Article The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia.
Academic Article Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection.
Academic Article Exposure and resistance to lantibiotics impact microbiota composition and function.
Search Criteria
  • Microbiome