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One or more keywords matched the following properties of Pamer, Eric
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overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Concept Mice, Inbred C3H
Concept Mice, Inbred A
Concept Mice, Inbred Strains
Concept Mice, Inbred CBA
Concept Mice, Transgenic
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Mice, Inbred DBA
Concept Mice, Knockout
Concept Mice, Congenic
Concept Mice
Concept Mice, Mutant Strains
Concept Mice, SCID
Concept Mice, Inbred NOD
Academic Article Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Academic Article Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae.
Academic Article Differing roles of inflammation and antigen in T cell proliferation and memory generation.
Academic Article Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice.
Academic Article Early programming of T cell populations responding to bacterial infection.
Academic Article Ecological modeling from time-series inference: insight into dynamics and stability of intestinal microbiota.
Academic Article Rescue of CD8 T cell-mediated antimicrobial immunity with a nonspecific inflammatory stimulus.
Academic Article Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.
Academic Article Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection.
Academic Article Immunology. Giving credit where credit is due.
Academic Article Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Academic Article Essential yet limited role for CCR2? inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming.
Academic Article Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope.
Academic Article Priming of memory but not effector CD8 T cells by a killed bacterial vaccine.
Academic Article Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.
Academic Article Promiscuity of MHC class Ib-restricted T cell responses.
Academic Article A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule.
Academic Article MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.
Academic Article Voriconazole inhibits fungal growth without impairing antigen presentation or T-cell activation.
Academic Article Immunodominant and subdominant CTL responses to Listeria monocytogenes infection.
Academic Article T lymphocyte dynamics during Listeria monocytogenes infection.
Academic Article Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure.
Academic Article Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment.
Academic Article H2-M3-restricted T cells in bacterial infection: rapid primary but diminished memory responses.
Academic Article Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Academic Article Distinct regulation of H2-M3-restricted memory T cell responses in lymph node and spleen.
Academic Article Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia.
Academic Article Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands.
Academic Article Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Academic Article Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.
Academic Article Monocyte-mediated immune defense against murine Listeria monocytogenes infection.
Academic Article Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Academic Article Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes.
Academic Article Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence.
Academic Article Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation.
Academic Article Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.
Academic Article The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus.
Academic Article H-2M3 presents a Listeria monocytogenes peptide to cytotoxic T lymphocytes.
Academic Article Processing of Listeria monocytogenes antigens and the in vivo T-cell response to bacterial infection.
Academic Article Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
Academic Article Immune responses to Listeria monocytogenes.
Academic Article Animal model for infection with Listeria monocytogenes.
Academic Article Memory phenotype CD8(+) T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes.
Academic Article Peptide presentation by the MHC class Ib molecule, H2-M3.
Academic Article Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance.
Academic Article MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses.
Academic Article CD8 T cell responses to infectious pathogens.
Academic Article Variable immunodominance hierarchies for H2-M3-restricted N-formyl peptides following bacterial infection.
Academic Article Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.
Academic Article Bile acid sensitivity and in vivo virulence of clinical Clostridium difficile isolates.
Academic Article Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen.
Academic Article The CD40-CD154 system in anti-infective host defense.
Academic Article Pathogen-specific CD8 T cell responses are directly inhibited by IL-10.
Academic Article The effects of amine-modified single-walled carbon nanotubes on the mouse microbiota.
Academic Article TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article T cell affinity maturation by selective expansion during infection.
Academic Article In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Academic Article Distinct Contributions of Neutrophils and CCR2+ Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains.
Academic Article Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.
Academic Article Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model.
Academic Article Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.
Academic Article The role of CD1-restricted T cells in infectious diseases.
Academic Article MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL.
Academic Article CD8 T cell detection of bacterial infection: sniffing for formyl peptides derived from Mycobacterium tuberculosis.
Academic Article CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
Academic Article Immunology. Dispensable but not irrelevant.
Academic Article Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells.
Academic Article Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection.
Academic Article Commensal microbiota affects ischemic stroke outcome by regulating intestinal ?d T cells.
Academic Article Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.
Academic Article Control of T cell antigen reactivity via programmed TCR downregulation.
Academic Article In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity.
Academic Article Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice.
Academic Article MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens.
Academic Article Tipping the balance in favor of protective immunity during influenza virus infection.
Academic Article Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice.
Academic Article Commensal microbes provide first line defense against Listeria monocytogenes infection.
Academic Article Bacterial pathogens: A spoonful of sugar could be the medicine.
Academic Article Coordinate regulation of complex T cell populations responding to bacterial infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells.
Academic Article Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Academic Article Noncompetitive expansion of cytotoxic T lymphocytes specific for different antigens during bacterial infection.
Academic Article The cellular and molecular origin of tumor-associated macrophages.
Academic Article The fate of low affinity tumor-specific CD8+ T cells in tumor-bearing mice.
Academic Article A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.
Academic Article Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.
Academic Article Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.
Academic Article A nonamer peptide derived from Listeria monocytogenes metalloprotease is presented to cytolytic T lymphocytes.
Academic Article Selective expansion of the monocytic lineage directed by bacterial infection.
Academic Article High-level primary CD8(+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses.
Academic Article Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections.
Academic Article Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule.
Academic Article Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection.
Academic Article A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection.
Academic Article Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation.
Academic Article Microbial Tuning of the Mammalian Immune System.
Academic Article Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
Academic Article Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article Rapid development of T cell memory.
Academic Article Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Academic Article Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.
Academic Article Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas.
Academic Article MHC class Jb-restricted cell responses to Listeria monocytogenes infection.
Academic Article Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis.
Academic Article Efficiency of MHC class I antigen processing: a quantitative analysis.
Academic Article Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes.
Academic Article Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion.
Academic Article Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis.
Academic Article Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
Academic Article Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
Academic Article MHC class I restricted T cell responses to Listeria monocytogenes, an intracellular bacterial pathogen.
Academic Article Intestinal and splenic T cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes.
Academic Article Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.
Academic Article TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection.
Academic Article Short- and long-term effects of oral vancomycin on the human intestinal microbiota.
Academic Article Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization.
Academic Article Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
Academic Article Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article TLR polymorphisms and the risk of invasive fungal infections.
Academic Article Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes.
Academic Article Effect of antigen-processing efficiency on in vivo T cell response magnitudes.
Academic Article Cutting edge: antigen-independent CD8 T cell proliferation.
Academic Article A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Academic Article Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.
Academic Article Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers.
Academic Article Dynamic imaging of the effector immune response to listeria infection in vivo.
Academic Article Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection.
Academic Article Critical role for MyD88-mediated neutrophil recruitment during Clostridium difficile colitis.
Academic Article Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.
Academic Article Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins.
Academic Article Feedback regulation of pathogen-specific T cell priming.
Academic Article Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes.
Academic Article Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.
Academic Article Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display.
Academic Article Robust recall and long-term memory T-cell responses induced by prime-boost regimens with heterologous live viral vectors expressing human immunodeficiency virus type 1 Gag and Env proteins.
Academic Article Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.
Academic Article H2-M3-restricted memory T cells: persistence and activation without expansion.
Academic Article Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus.
Academic Article Lactose drives Enterococcus expansion to promote graft-versus-host disease.
Academic Article Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.
Academic Article Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine.
Academic Article Antibiotic Degradation by Commensal Microbes Shields Pathogens.
Academic Article Outbreaks of Typhlocolitis Caused by Hypervirulent Group ST1 Clostridioides difficile in Highly Immunocompromised Strains of Mice.
Academic Article Enhancing mucosal immunity by transient microbiota depletion.
Academic Article Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation.
Academic Article TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
Grant Characterization of Aspergillus fumigatus specific CD4 T cell responses.
Grant CC-chemokines in Listeria infection.
Grant Innate Immune Responses to Microbial Flora
Grant H2-M3 RESTRICTED T CELL RESPONSES
Grant CD4 T Cell Responses to M. Tuberculosis Infection
Grant Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant Inflammation and T cell immunity to Listeria
Academic Article Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile.
Academic Article Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.
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