Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

Connection

Search Results to Eric Pamer

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Pamer, Eric

PropertyValue
overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.

One or more keywords matched the following items that are connected to Pamer, Eric

Item TypeName
Concept Drug Resistance
Concept Lupus Erythematosus, Systemic
Concept beta-Lactam Resistance
Concept Drug Resistance, Multiple, Bacterial
Concept Vancomycin Resistance
Concept Drug Resistance, Bacterial
Concept Disease Resistance
Concept Drug Resistance, Microbial
Academic Article Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae.
Academic Article Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.
Academic Article Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.
Academic Article MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection.
Academic Article The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens.
Academic Article Enlisting commensal microbes to resist antibiotic-resistant pathogens.
Academic Article Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands.
Academic Article Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.
Academic Article Microbiota-mediated inflammation and antimicrobial defense in the intestine.
Academic Article Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Academic Article Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?
Academic Article Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.
Academic Article Intestinal Bile Acids Induce a Morphotype Switch in Vancomycin-Resistant Enterococcus that Facilitates Intestinal Colonization.
Academic Article Loss of Microbiota-Mediated Colonization Resistance to Clostridium difficile Infection With Oral Vancomycin Compared With Metronidazole.
Academic Article Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.
Academic Article Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation.
Academic Article Microbiota-mediated colonization resistance against intestinal pathogens.
Academic Article MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.
Academic Article Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification.
Academic Article Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus.
Academic Article Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
Academic Article Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection.
Academic Article Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens.
Academic Article Correction: Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization.
Academic Article The changing epidemiology of vancomycin-resistant Enterococcus (VRE) bacteremia in allogeneic hematopoietic stem cell transplant (HSCT) recipients.
Academic Article Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.
Academic Article Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections.
Academic Article Robust recall and long-term memory T-cell responses induced by prime-boost regimens with heterologous live viral vectors expressing human immunodeficiency virus type 1 Gag and Env proteins.
Academic Article Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus.
Academic Article Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV.
Academic Article Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.
Academic Article Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine.
Academic Article Antibiotic Degradation by Commensal Microbes Shields Pathogens.

Search Criteria
  • induced
  • systemic
  • resistance