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One or more keywords matched the following properties of Pamer, Eric
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overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Concept Bacteria
Concept Gram-Positive Bacteria
Concept Influenza A virus
Concept Gram-Negative Bacteria
Concept Vaccinia virus
Concept Epstein-Barr Virus Nuclear Antigens
Concept Virus Latency
Concept Influenza A Virus, H1N1 Subtype
Concept Hemagglutinin Glycoproteins, Influenza Virus
Concept Vesicular stomatitis Indiana virus
Concept Virus Activation
Concept Virus Diseases
Concept Epstein-Barr Virus Infections
Academic Article Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness.
Academic Article Immune responses to commensal and environmental microbes.
Academic Article Innate immune signaling in defense against intestinal microbes.
Academic Article Enlisting commensal microbes to resist antibiotic-resistant pathogens.
Academic Article Antibiotic-Induced Changes in the Intestinal Microbiota and Disease.
Academic Article Role of the commensal microbiota in normal and pathogenic host immune responses.
Academic Article Predictors for persistent cytomegalovirus reactivation after T-cell-depleted allogeneic hematopoietic stem cell transplantation.
Academic Article Gut microbiota dysbiosis and diarrhea in kidney transplant recipients.
Academic Article Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus.
Academic Article Quantitation, selection, and functional characterization of Epstein-Barr virus-specific and alloreactive T cells detected by intracellular interferon-gamma production and growth of cytotoxic precursors.
Academic Article The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study.
Academic Article Commensal bacteria mediated defenses against pathogens.
Academic Article CD8 T cell responses to infectious pathogens.
Academic Article Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study.
Academic Article The effects of amine-modified single-walled carbon nanotubes on the mouse microbiota.
Academic Article Microbiota-mediated colonization resistance against intestinal pathogens.
Academic Article Intestinal Blautia Is Associated with Reduced Death from Graft-versus-Host Disease.
Academic Article Commensal microbiota affects ischemic stroke outcome by regulating intestinal ?d T cells.
Academic Article The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation.
Academic Article In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity.
Academic Article Tipping the balance in favor of protective immunity during influenza virus infection.
Academic Article Defective CD8+ T cell peripheral tolerance in nonobese diabetic mice.
Academic Article Commensal microbes provide first line defense against Listeria monocytogenes infection.
Academic Article Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.
Academic Article The fate of low affinity tumor-specific CD8+ T cells in tumor-bearing mice.
Academic Article Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus.
Academic Article Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.
Academic Article High-level primary CD8(+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses.
Academic Article Cellular immunity to intracellular bacteria.
Academic Article A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection.
Academic Article Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile-induced colitis.
Academic Article Characterization of CD8+ T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas.
Academic Article 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients.
Academic Article Gut microbiota and tacrolimus dosing in kidney transplantation.
Academic Article Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens.
Academic Article Regulation of innate and adaptive immunity by the commensal microbiota.
Academic Article Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.
Academic Article Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.
Academic Article Robust recall and long-term memory T-cell responses induced by prime-boost regimens with heterologous live viral vectors expressing human immunodeficiency virus type 1 Gag and Env proteins.
Academic Article Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease.
Academic Article Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT.
Academic Article Microbiota-derived lantibiotic restores resistance against vancomycin-resistant Enterococcus.
Academic Article Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study.
Academic Article Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.
Academic Article Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine.
Academic Article Antibiotic Degradation by Commensal Microbes Shields Pathogens.
Academic Article Compositional Flux Within the Intestinal Microbiota and Risk for Bloodstream Infection With Gram-negative Bacteria.
Academic Article The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD.
Academic Article Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection.
Academic Article Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation.
Academic Article A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia.
Grant Innate immune defense against clostridium Difficile Infection
Grant Innate Immune Responses to Microbial Flora
Grant Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant Pathogens
Grant CYTOTOXIC T LYMPHOCYTE RESPONSE TO BACTERIAL INFECTION
Grant Inflammation and T cell immunity to Listeria
Academic Article Assembling symbiotic bacterial species into live therapeutic consortia that reconstitute microbiome functions.
Academic Article The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia.
Academic Article Corrigendum: A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia.
Academic Article An evolution-based framework for describing human gut bacteria.
Academic Article Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
Academic Article Activity of Gut-Derived Nisin-like Lantibiotics against Human Gut Pathogens and Commensals.
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  • viruses
  • bacteria
  • commensal
  • microbes