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Concept
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Leiomyoma
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Academic Article
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Role of vitamin D in uterine fibroid biology.
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Academic Article
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Vitamin D3 Inhibits Wnt/ß-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells.
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Academic Article
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Vitamin D and uterine fibroids: preclinical evidence is in; time for an overdue clinical study!
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Academic Article
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Can vitamin D reduce the risk of uterine fibroids?
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Academic Article
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Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study.
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Academic Article
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Elagolix Treatment for Up to 12 Months in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas.
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Academic Article
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Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model.
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Academic Article
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Gene therapy and uterine leiomyoma: a review.
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Academic Article
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The Polycomb Group Protein EZH2 Impairs DNA Damage Repair Gene Expression in Human Uterine Fibroids.
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Academic Article
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Uterine Fibroids: Burden and Unmet Medical Need.
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Academic Article
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Expanding upon the Human Myometrial Stem Cell Hypothesis and the Role of Race, Hormones, Age, and Parity in a Profibroid Environment.
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Academic Article
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Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression.
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Academic Article
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Berberine Inhibits Uterine Leiomyoma Cell Proliferation via Downregulation of Cyclooxygenase 2 and Pituitary Tumor-Transforming Gene 1.
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Academic Article
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Adipocytes enhance the proliferation of human leiomyoma cells via TNF-a proinflammatory cytokine.
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Academic Article
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1,25-dihydroxyvitamin D3 regulates expression of sex steroid receptors in human uterine fibroid cells.
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Academic Article
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Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma.
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Academic Article
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Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids.
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Academic Article
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Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial.
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Academic Article
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Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans.
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Academic Article
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Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids.
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Academic Article
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Uterine fibroids in menopause and perimenopause.
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Academic Article
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Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids.
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Academic Article
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Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/ß-Catenin Signaling Pathway.
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Academic Article
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Uterine fibroids are characterized by an impaired antioxidant cellular system: potential role of hypoxia in the pathophysiology of uterine fibroids.
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Academic Article
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Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice.
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Academic Article
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Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma.
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Academic Article
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Stro-1/CD44 as putative human myometrial and fibroid stem cell markers.
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Academic Article
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Myometrial progesterone hyper-responsiveness associated with increased risk of human uterine fibroids.
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Academic Article
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Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids.
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Academic Article
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The Selective Progesterone Receptor Modulator Ulipristal Acetate Inhibits the Activity of the Glucocorticoid Receptor.
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Academic Article
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Molecular genetics and racial disparities of uterine leiomyomas.
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Academic Article
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Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic Regulation.
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Academic Article
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Converting of Myometrial Stem Cells to Tumor-Initiating Cells: Mechanism of Uterine Fibroid Development.
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Academic Article
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Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells.
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Academic Article
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1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model.
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Academic Article
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Gene therapy of benign gynecological diseases.
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Academic Article
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Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroids.
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Academic Article
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Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas.
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Academic Article
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A Preliminary Study: Human Fibroid Stro-1+/CD44+ Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1+/CD44+ Cells.
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Academic Article
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The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids.
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Academic Article
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Vitamin D, a promising natural compound with anti-uterine fibroid characteristics.
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Academic Article
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1,25-dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells.
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Academic Article
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Burden, Prevalence, and Treatment of Uterine Fibroids: A Survey of U.S. Women.
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Academic Article
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Molecular Bio-Imaging Probe for Non-Invasive Differentiation Between Human Leiomyoma Versus Leiomyosarcoma.
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Academic Article
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Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice.
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Academic Article
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Oxidative stress: a key regulator of leiomyoma cell survival.
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Academic Article
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Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells.
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Academic Article
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Introduction of Somatic Mutation in MED12 Induces Wnt4/ß-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell.
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Academic Article
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Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy.
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Academic Article
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Successes and failures of uterine leiomyoma drug discovery.
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Academic Article
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Simvastatin and uterine fibroids: opportunity for a novel therapeutic option.
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Academic Article
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1,25 Dihydroxyvitamin D3 Enhances the Antifibroid Effects of Ulipristal Acetate in Human Uterine Fibroids.
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Academic Article
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Targeted Adenoviral Vector Demonstrates Enhanced Efficacy for In Vivo Gene Therapy of Uterine Leiomyoma.
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Academic Article
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Uterine Leiomyoma: New Perspectives on an Old Disease.
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Academic Article
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Origin of Uterine Fibroids: Conversion of Myometrial Stem Cells to Tumor-Initiating Cells.
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Academic Article
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Uterine Fibroids: Bridging Genomic Defects and Chronic Inflammation.
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Academic Article
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Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids.
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Academic Article
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Hypovitaminosis D and high serum transforming growth factor beta-3: important biomarkers for uterine fibroids risk.
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Academic Article
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Vitamin D3 Ameliorates DNA Damage Caused by Developmental Exposure to Endocrine Disruptors in the Uterine Myometrial Stem Cells of Eker Rats.
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Academic Article
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Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study.
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Academic Article
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Potential nonhormonal therapeutics for medical treatment of leiomyomas.
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Academic Article
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Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells.
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Academic Article
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Toward gene therapy of uterine fibroids: targeting modified adenovirus to human leiomyoma cells.
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Academic Article
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Neurotrimin: a novel neural cell adhesion molecule correlating with uterine fibroid phenotype.
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Academic Article
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Innovative oral treatments of uterine leiomyoma.
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Academic Article
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Berberine inhibits the proliferation of human uterine leiomyoma cells.
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Academic Article
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Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas.
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Academic Article
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Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.
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Academic Article
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Predictors of response for elagolix with add-back therapy in women with heavy menstrual bleeding associated with uterine fibroids.
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Academic Article
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Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
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Academic Article
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Activation of ß-Catenin Signaling and its Crosstalk With Estrogen and Histone Deacetylases in Human Uterine Fibroids.
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Academic Article
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Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study.
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Academic Article
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Alcohol Consumption and Risk of Uterine Fibroids.
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Academic Article
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Non-coding RNAs: an important regulatory mechanism in pathogenesis of uterine fibroids.
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Academic Article
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Endocrine disruptor exposure during development increases incidence of uterine fibroids by altering DNA repair in myometrial stem cells.
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Academic Article
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Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice.
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Academic Article
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Targeting the transforming growth factor-ß pathway: a novel mechanism of ulipristal acetate action against uterine fibroids.
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Academic Article
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Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups.
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Academic Article
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1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells.
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Academic Article
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Paricalcitol, a vitamin d receptor activator, inhibits tumor formation in a murine model of uterine fibroids.
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Academic Article
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Green tea extract inhibition of human leiomyoma cell proliferation is mediated via catechol-O-methyltransferase.
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Academic Article
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Medical treatment of uterine leiomyoma.
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Academic Article
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Identification and potential role of telocytes in human uterine leiomyoma.
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Academic Article
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Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model.
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Academic Article
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Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas.
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Academic Article
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Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications.
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Academic Article
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Evolving role of microRNAs in uterine fibroid pathogenesis: filling the gap!
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Academic Article
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Gene therapy of uterine leiomyoma: adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir treatment inhibits growth of human and rat leiomyoma cells in vitro and in a nude mouse model.
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Academic Article
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Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells.
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Academic Article
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Burden of Uterine Fibroids: An African Perspective, A Call for Action and Opportunity for Intervention.
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Academic Article
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Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment.
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Academic Article
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Endocrine-disrupting chemicals and uterine fibroids.
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Academic Article
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Ulipristal Acetate for Treatment of Symptomatic Uterine Leiomyomas: A Randomized Controlled Trial.
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Academic Article
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Uterine fibroid therapy: the pharmacokinetic considerations.
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Academic Article
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The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.
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Academic Article
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H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas.
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Academic Article
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Towards fibroid gene therapy: adenovirus-mediated delivery of herpes simplex virus 1 thymidine kinase gene/ganciclovir shrinks uterine leiomyoma in the Eker rat model.
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Academic Article
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Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis.
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Academic Article
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Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance.
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Academic Article
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Non-hormonal mediators of uterine fibroid growth.
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Academic Article
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The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis.
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Academic Article
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The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids.
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Academic Article
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Targeting Hedgehog Pathway and DNA Methyltransferases in Uterine Leiomyosarcoma Cells.
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Academic Article
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Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.
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Academic Article
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Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients.
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Academic Article
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Understanding the Impact of Uterine Fibroids on Human Endometrium Function.
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Academic Article
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Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting: New Developments February 28, 2020.
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Academic Article
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Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation.
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Academic Article
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Reduction of Heavy Menstrual Bleeding in Women Not Designated as Responders to Elagolix Plus Add Back Therapy for Uterine Fibroids.
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Academic Article
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Current approaches to overcome the side effects of GnRH analogs in the treatment of patients with uterine fibroids.
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Academic Article
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Endocrine-Disrupting Chemicals and Vitamin D Deficiency in the Pathogenesis of Uterine Fibroids.
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Academic Article
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Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.
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Academic Article
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An evaluation of relugolix/estradiol/norethindrone acetate for the treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.
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Academic Article
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Simvastatin inhibits stem cell proliferation in human leiomyoma via TGF-ß3 and Wnt/ß-Catenin pathways.
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Academic Article
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A Call-to-Action for Clinicians to Implement Evidence-Based Best Practices When Caring for Women with Uterine Fibroids.
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Academic Article
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Epigenetic Regulation in Uterine Fibroids-The Role of Ten-Eleven Translocation Enzymes and Their Potential Therapeutic Application.
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Academic Article
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Adverse childhood experiences and health-related quality of life among women undergoing hysterectomy for uterine leiomyoma.
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Academic Article
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Human Myometrial and Uterine Fibroid Stem Cell-Derived Organoids for Intervening the Pathophysiology of Uterine Fibroid.
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Academic Article
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Report of Exosomes Isolated from a Human Uterine Leiomyoma Cell Line and Their Impact on Endometrial Vascular Endothelial Cells.
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Academic Article
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Relugolix Combination Therapy for Uterine Leiomyoma-Associated Pain in the LIBERTY Randomized Trials.
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Academic Article
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The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma.
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Academic Article
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Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
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Academic Article
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Uterine fibroids - Causes, impact, treatment, and lens to the African perspective.
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Academic Article
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Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials.
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Academic Article
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Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
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Academic Article
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Quality of life with relugolix combination therapy for uterine fibroids: LIBERTY randomized trials.
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Academic Article
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Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil.
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Grant
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Targeting Adenovirus for Gene Therapy of Uterine Leiomyoma
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Grant
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Gene X Environment Interactions in the Pathogenesis of Uterine Fibroids
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Grant
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Hypovitaminosis D promotes MED12-associated genomic instability in uterine fibroids
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Grant
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Pathological reprogramming of the m6A epitranscriptome in uterine fibroids
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Grant
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3/4, University of Illinois at Chicago Clinical Site- Reproductive Medicine Collaborative Consortium: A randomized placebo-controlled trial of EGCG to improve fertility in women with uterine fibroids
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Academic Article
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A plain language summary of the safety of relugolix combination therapy and improvement in symptoms in women with uterine fibroids from the LIBERTY 1 and LIBERTY 2 studies.
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Academic Article
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Update on the Role and Regulatory Mechanism of Extracellular Matrix in the Pathogenesis of Uterine Fibroids.
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Academic Article
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EZH2 activates Wnt/ß-catenin signaling in human uterine fibroids, which is inhibited by the natural compound methyl jasmonate.
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Academic Article
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Progesterone Signaling and Uterine Fibroid Pathogenesis; Molecular Mechanisms and Potential Therapeutics.
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Academic Article
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GnRH analogs for the treatment of heavy menstrual bleeding associated with uterine fibroids.
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Academic Article
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Efficacy and safety of vilaprisan in women with uterine fibroids: data from the ASTEROID 3 randomized controlled trial.
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Academic Article
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A plain language summary of the long-term relugolix combination therapy study for uterine fibroids.
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Academic Article
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Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine Fibroids.
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Academic Article
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Prevention of Uterine Fibroids: molecular mechanisms and potential clinical application.
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Academic Article
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TGFß signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells.
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Academic Article
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Uterine Fibroids: A Podcast on Patient and Physician Perspectives on Medical Management and a New Medical Therapy (Relugolix Combination Therapy).
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Academic Article
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GnRH agonists and antagonists in therapy of symptomatic uterine fibroids - current roles and future perspectives.
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Academic Article
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Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids.
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Academic Article
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LIBERTY randomized withdrawal study: relugolix combination therapy for heavy menstrual bleeding associated with uterine fibroids.
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Academic Article
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The combination of natural compounds Crila and epigallocatechin gallate showed enhanced antiproliferative effects on human uterine fibroid cells compared with single treatments.
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Academic Article
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Relugolix Combination Therapy in Black/African American Women with Symptomatic Uterine Fibroids: LIBERTY Long-Term Extension Study.
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Academic Article
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Current and Emerging Treatment Options for Uterine Fibroids.
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