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One or more keywords matched the following properties of Chen, Jing
keywords Cancer Metabolism
overview Dr. Chen is interested in elucidating the signaling interplay between metabolic and cell signaling networks for a better understanding of cancer metabolism and improved clinical outcome. Two major research focuses include (1) To determine both metabolic and signaling functions of intracellular metabolites and circulating “blood chemicals”, which influence tumorigenesis and tumor progression, and responses to anti-cancer therapies including chemotherapy and immunotherapy; and (2) To decipher mechanistic basis underlying the pathogenic links between diets and particular oncogenic mutations by exploring the pro- and anti-tumor effects of diet-derived substances on tumors with specific genetic backgrounds.
One or more keywords matched the following items that are connected to Chen, Jing
Item TypeName
Concept Lung Neoplasms
Concept Head and Neck Neoplasms
Concept Neoplasms, Experimental
Concept Skin Neoplasms
Concept Neoplasms
Academic Article Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Academic Article Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Academic Article Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Academic Article 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Academic Article Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Academic Article Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Academic Article p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Academic Article Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Award or Honor Receipt GCC Distinguished Cancer Scholar
Award or Honor Receipt ACS Basic Research Scholar Award
Award or Honor Receipt Winship 5K Scholar Award
Award or Honor Receipt Winship Cancer Institute Research Mentorship Award
Academic Article Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer.
Academic Article The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Academic Article FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Academic Article ?-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A.
Academic Article Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
Grant Oxidative pentose phosphate pathway regulates AMPK homeostasis by balancing opposing LKB1 and PP2A
Academic Article Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity.
Search Criteria
  • Cancer
  • Metabolism