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Search Results to Jing Chen

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One or more keywords matched the following properties of Chen, Jing

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keywords Signal Transductions
keywords Metabolites as signaling molecules
overview Dr. Chen is interested in elucidating the signaling interplay between metabolic and cell signaling networks for a better understanding of cancer metabolism and improved clinical outcome. Two major research focuses include (1) To determine both metabolic and signaling functions of intracellular metabolites and circulating “blood chemicals”, which influence tumorigenesis and tumor progression, and responses to anti-cancer therapies including chemotherapy and immunotherapy; and (2) To decipher mechanistic basis underlying the pathogenic links between diets and particular oncogenic mutations by exploring the pro- and anti-tumor effects of diet-derived substances on tumors with specific genetic backgrounds.

One or more keywords matched the following items that are connected to Chen, Jing

Item TypeName
Concept Carcinoma, Squamous Cell
Concept Cell Transformation, Neoplastic
Concept Cell Proliferation
Concept NIH 3T3 Cells
Concept HEK293 Cells
Concept HT29 Cells
Concept K562 Cells
Concept MAP Kinase Signaling System
Concept Extracellular Signal-Regulated MAP Kinases
Concept Cell Line, Tumor
Concept Cell Line
Concept Leukemia, Hairy Cell
Concept Signal Transduction
Academic Article Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Academic Article Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.
Academic Article Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Academic Article 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Academic Article Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
Academic Article Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Academic Article p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.
Academic Article Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.
Academic Article Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth.
Academic Article Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer.
Academic Article The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.
Academic Article Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth.
Academic Article FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.
Academic Article ?-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A.
Academic Article Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.
Academic Article Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Molecular Cell (accepted and in press)

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  • Cell
  • signaling