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Search Results to Mark Applebaum

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overview Mark Applebaum, MD, is an expert in pediatric cancers and blood diseases. He has a special interest in the treatment of neuroblastoma, sarcomas and solid tumors. Dr. Applebaum is a translational physician-scientist working on harnessing genomics and “big data” to advance treatments for children with neuroblastoma. He bridges the fields of epigenetics, genomics, and cancer biology to identify idenitfy novel risk classifiers and therapeutic targets. Dr. Applebaum focuses his research on how specific epigenetic marks can identify patients with aggressive neuroblastoma that may benefit from alternatives to standard therapy. His laboratory is also identifying how the low-oxygen environment of tumors makes cancer cells more resistant to standard therapies by inducing changes in these same epigenetic marks. Identifying the genes and cellular pathways responsible for these changes may ultimately open new avenues for novel therapeutic options. Dr. Applebaum's research is supported by the National Cancer Institute and the University of Chicago Cancer Center Auxiliary Board. He has received funding from the Conquer Cancer Foundation, Cancer Research Foundation, and the Bear Necessities Foundation. He is the recipient of numerous awards from the American Society of Clinical Oncology, the American Association of Cancer Researchers, and the Advances in Neuroblastoma Research Association.

One or more keywords matched the following items that are connected to Applebaum, Mark

Item TypeName
Concept Bone Neoplasms
Concept Pediatrics
Concept Soft Tissue Neoplasms
Concept Neoplasms, Second Primary
Concept Neoplasms
Academic Article Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement.
Academic Article Second malignancies in patients with neuroblastoma: the effects of risk-based therapy.
Academic Article Evaluation of plasma annexin V levels in children and young adults with solid tumors.
Academic Article Clinical features and outcomes in patients with secondary Ewing sarcoma.
Academic Article Clinical features and outcomes in patients with extraskeletal Ewing sarcoma.
Academic Article Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
Academic Article Surveillance of Childhood Cancer Survivors: A Lifelong Affair.
Academic Article Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence.
Academic Article Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project.
Academic Article Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma.
Academic Article Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma.
Academic Article Progress toward liquid biopsies in pediatric solid tumors.
Academic Article 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article A conversation with my personal oncologist.
Academic Article Association between end-induction response according to the revised International Neuroblastoma Response Criteria (INRC) and outcome in high-risk neuroblastoma patients.
Academic Article Association Between Participation in Clinical Trials and Overall Survival Among Children With Intermediate- or High-risk Neuroblastoma.
Academic Article Predicting Response to Chemotherapy in Patients With Newly Diagnosed High-Risk Neuroblastoma: A Report From the International Neuroblastoma Risk Group.
Academic Article Applications of Artificial Intelligence in Pediatric Oncology: A Systematic Review.
Academic Article Germline Sequencing Improves Tumor-Only Sequencing Interpretation in a Precision Genomic Study of Patients With Pediatric Solid Tumor.
Academic Article Efficacy of post-induction therapy for high-risk neuroblastoma patients with end-induction residual disease.
Academic Article Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.

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  • cancer