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One or more keywords matched the following properties of Comstock, Laurie
keywords Microbiome
keywords Microbiota
overview The human intestinal microbiota is a complex and dynamic consortium of microbes that is crucial for human health and disease prevention. Our lab has been studying the abundant bacterial members of this ecosystem to understand how they interact with each other both cooperatively and antagonistically to form these health-promoting communities. We use basic microbiological, genetic, biochemical, and gnotobiotic mouse analyses, combined with genomic, metagenomic and computational analyses to understand these complex interactions. We have discovered numerous classes of new antimicrobial proteins that these bacteria use to compete in their ecosystem, and we are studying their mechanisms of action, ecological properties, and how we may translate these molecules for human health benefits. Another focus of the lab is the evolution of microbes in the human gut and how genetic elements horizontally transferred between bacterial species personalize each individual’s gut microbiota and the phenotypes and community benefits conferred by these shared genetic elements.
One or more keywords matched the following items that are connected to Comstock, Laurie
Item TypeName
Academic Article Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism.
Academic Article A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota.
Academic Article Type VI Secretion Systems and the Gut Microbiota.
Academic Article Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements.
Academic Article The evolution of cooperation within the gut microbiota.
Academic Article Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota.
Academic Article Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.
Academic Article Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species.
Academic Article Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts.
Academic Article Immunology: Starve a fever, feed the microbiota.
Academic Article Bacterial antagonism in host-associated microbial communities.
Academic Article Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.
Academic Article Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.
Academic Article The Host Shapes the Gut Microbiota via Fecal MicroRNA.
Academic Article Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis.
Academic Article Production of a-galactosylceramide by a prominent member of the human gut microbiota.
Academic Article Bacteroidetocins Target the Essential Outer Membrane Protein BamA of Bacteroidales Symbionts and Pathogens.
Concept Gastrointestinal Microbiome
Academic Article A ubiquitous mobile genetic element disarms a bacterial antagonist of the gut microbiota.
Academic Article Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.
Grant Contact-Dependent Antagonism in Gut Bacteroidales
Grant Regulation of the multiple polysaccharides of Bacteroides fragilis
Grant A new paradigm of respiration in the human gut Bacteroides
Grant Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
Grant Regulation of the multiple polysaccharides of Bacteroides fragilis
Grant Secreted antimicrobial proteins of the intestinal Bacteriodales
Grant Significance of Bacteroides fragilis polysaccharide phase variation
Academic Article A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations.
Academic Article Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome.
Academic Article Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
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  • Microbiome