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One or more keywords matched the following properties of Comstock, Laurie
PropertyValue
keywords Bacterial interactions
overview The human intestinal microbiota is a complex and dynamic consortium of microbes that is crucial for human health and disease prevention. Our lab has been studying the abundant bacterial members of this ecosystem to understand how they interact with each other both cooperatively and antagonistically to form these health-promoting communities. We use basic microbiological, genetic, biochemical, and gnotobiotic mouse analyses, combined with genomic, metagenomic and computational analyses to understand these complex interactions. We have discovered numerous classes of new antimicrobial proteins that these bacteria use to compete in their ecosystem, and we are studying their mechanisms of action, ecological properties, and how we may translate these molecules for human health benefits. Another focus of the lab is the evolution of microbes in the human gut and how genetic elements horizontally transferred between bacterial species personalize each individual’s gut microbiota and the phenotypes and community benefits conferred by these shared genetic elements.
One or more keywords matched the following items that are connected to Comstock, Laurie
Item TypeName
Concept Species Specificity
Concept Host-Pathogen Interactions
Concept Microbial Interactions
Academic Article Expression of phase variable surface molecules of Bacteroides species from healthy and clinical stool.
Academic Article Friend turned foe: a role for bacterial sulfatases in colitis.
Academic Article Evidence of extensive DNA transfer between bacteroidales species within the human gut.
Academic Article Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species.
Academic Article Small RNAs Repress Expression of Polysaccharide Utilization Loci of Gut Bacteroides Species.
Academic Article Bacterial antagonism in host-associated microbial communities.
Academic Article Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.
Academic Article Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.
Academic Article "Cross-glycosylation" of proteins in Bacteroidales species.
Academic Article Longitudinal analysis of the prevalence, maintenance, and IgA response to species of the order Bacteroidales in the human gut.
Academic Article The capsule and O antigen in Vibrio cholerae O139 Bengal are associated with a genetic region not present in Vibrio cholerae O1.
Academic Article Interaction of Lyme disease spirochetes with cultured eucaryotic cells.
Academic Article Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139: specificity and relevance to immunity.
Academic Article Cloning and sequence of a region encoding a surface polysaccharide of Vibrio cholerae O139 and characterization of the insertion site in the chromosome of Vibrio cholerae O1.
Academic Article Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
Academic Article Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution.
Grant Genetic Basis of Abscess Formation by B. fragilis
Grant Contact-Dependent Antagonism in Gut Bacteroidales
Grant Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
Grant FASEB Summer Conference on Microbial Polysaccharides
Grant Secreted antimicrobial proteins of the intestinal Bacteriodales
Academic Article Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution.
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  • Interaction