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overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Director of the Institute for Biophysical Dynamics at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, epigenetics, cell biology, molecular biology, biochemistry, structural biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects post-transcriptional gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item TypeName
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Leukemic
Concept Gene Expression Regulation, Plant
Concept Gene Expression Regulation, Bacterial
Concept Gene Expression Regulation, Neoplastic
Academic Article The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Academic Article A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article Unique features of the m6A methylome in Arabidopsis thaliana.
Academic Article Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article Dynamic RNA modifications in posttranscriptional regulation.
Academic Article Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.
Academic Article Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Academic Article Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
Academic Article Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Academic Article N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Academic Article RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Academic Article A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article Post-transcriptional gene regulation by mRNA modifications.
Academic Article The emerging biology of RNA post-transcriptional modifications.
Academic Article DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article Dynamic RNA Modifications in Gene Expression Regulation.
Academic Article Chemical Modifications in the Life of an mRNA Transcript.
Academic Article RNA modifications modulate gene expression during development.
Academic Article RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
Academic Article Special Issue on Regulating the Central Dogma.
Academic Article Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article Regulation of Gene Expression by N6-methyladenosine in Cancer.
Academic Article Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.

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