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He, Chuan

One or more keywords matched the following properties of He, Chuan

Property	Value
keywords	RNA modification
keywords	DNA methylation
overview	Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item Type	Name
Concept	DNA (Cytosine-5-)-Methyltransferases
Concept	RNA Precursors
Concept	RNA, Ribosomal, 28S
Concept	RNA, Bacterial
Concept	RNA, Neoplasm
Concept	RNA, Viral
Concept	RNA Splicing
Concept	RNA
Concept	RNA Polymerase II
Concept	DNA-Directed RNA Polymerases
Concept	RNA Processing, Post-Transcriptional
Concept	RNA, Transfer
Concept	RNA Splice Sites
Concept	RNA, Nuclear
Concept	RNA Interference
Concept	Methylation
Concept	RNA-Binding Proteins
Concept	RNA, Messenger, Stored
Concept	RNA Helicases
Concept	RNA, Small Nucleolar
Concept	RNA, Messenger
Concept	DNA Methylation
Concept	RNA, Plant
Concept	RNA, Untranslated
Concept	RNA Folding
Concept	RNA Transport
Concept	RNA, Small Interfering
Concept	Cytosine
Concept	RNA, Ribosomal
Concept	RNA, Ribosomal, 18S
Concept	RNA, Small Nuclear
Concept	DNA-Cytosine Methylases
Concept	Sequence Analysis, RNA
Concept	RNA Stability
Academic Article	Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article	The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article	Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.
Academic Article	Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article	A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article	N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Academic Article	Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article	FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article	Unique features of the m6A methylome in Arabidopsis thaliana.
Academic Article	A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article	N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article	Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.
Academic Article	ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Academic Article	Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article	Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article	Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article	Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.
Academic Article	A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).
Academic Article	Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Academic Article	Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article	Grand challenge commentary: RNA epigenetics?
Academic Article	Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article	Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Academic Article	Potential functional roles of DNA demethylation intermediates.
Academic Article	Dynamic RNA modifications in posttranscriptional regulation.
Academic Article	Pseudouridine in a new era of RNA modifications.
Academic Article	Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article	Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article	Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
Academic Article	N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions.
Academic Article	High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.
Academic Article	Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
Academic Article	Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article	A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article	Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
Academic Article	Nucleic acid modifications with epigenetic significance.
Academic Article	Detection of 5-hydroxymethylcytosine in DNA by transferring a keto-glucose by using T4 phage ß-glucosyltransferase.
Academic Article	A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine.
Academic Article	Reversible RNA adenosine methylation in biological regulation.
Academic Article	Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article	Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Academic Article	Nucleic acid oxidation in DNA damage repair and epigenetics.
Academic Article	Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article	Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article	Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.
Academic Article	Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article	Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
Academic Article	N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Academic Article	RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article	Decoding the transcriptome and DNA methylome of human primordial germ cells.
Academic Article	High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
Academic Article	Preparation of Human Nuclear RNA m6A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity.
Academic Article	Efficient and quantitative high-throughput tRNA sequencing.
Academic Article	DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Academic Article	Base-resolution detection of N4-methylcytosine in genomic DNA using 4mC-Tet-assisted-bisulfite- sequencing.
Academic Article	Detecting hepatocellular carcinoma in blood.
Academic Article	RNA epigenetics--chemical messages for posttranscriptional gene regulation.
Academic Article	Weakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability.
Academic Article	The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article	Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article	Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article	Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Academic Article	A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article	Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Academic Article	ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article	Post-transcriptional gene regulation by mRNA modifications.
Academic Article	The emerging biology of RNA post-transcriptional modifications.
Academic Article	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Academic Article	Evolution of transcript modification by N6-methyladenosine in primates.
Academic Article	YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.
Academic Article	m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.
Academic Article	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision.
Academic Article	Dynamic RNA Modifications in Gene Expression Regulation.
Academic Article	Chemical Modifications in the Life of an mRNA Transcript.
Academic Article	RNA modifications modulate gene expression during development.
Academic Article	m6A facilitates hippocampus-dependent learning and memory through YTHDF1.
Academic Article	Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
Academic Article	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Academic Article	m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article	Our views of dynamic N6-methyladenosine RNA methylation.
Academic Article	Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article	Identifying the m6A Methylome by Affinity Purification and Sequencing.
Academic Article	YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.
Academic Article	Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
Academic Article	Epitranscriptomic influences on development and disease.
Academic Article	Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article	High-Resolution Mapping of N 6-Methyladenosine Using m6A Crosslinking Immunoprecipitation Sequencing (m6A-CLIP-Seq).
Academic Article	Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome.
Grant	Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Academic Article	mRNA acetylation: a new addition to the epitranscriptome.
Academic Article	Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Academic Article	METTL14 is essential for ß-cell survival and insulin secretion.
Academic Article	Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article	FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.
Academic Article	Site-specific m6A editing.
Academic Article	Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Academic Article	Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA.
Academic Article	The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine-containing mRNAs.
Academic Article	5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article	RADAR: differential analysis of MeRIP-seq data with a random effect model.
Academic Article	m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Academic Article	N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
Academic Article	Keth-seq for transcriptome-wide RNA structure mapping.
Academic Article	DNA 5-Methylcytosine-Specific Amplification and Sequencing.
Academic Article	N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article	YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
Academic Article	REPIC: a database for exploring the N6-methyladenosine methylome.
Academic Article	Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
Academic Article	Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability.
Academic Article	A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m6A Methyltransferase Component METTL14 in T Cells.
Academic Article	Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
Academic Article	LEAD-m6 A-seq for Locus-Specific Detection of N6 -Methyladenosine and Quantification of Differential Methylation.
Academic Article	Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation.
Academic Article	N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Academic Article	A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article	Global Detection of RNA Methylation by Click Degradation.
Academic Article	m6 A RNA methylation: from mechanisms to therapeutic potential.
Academic Article	Chromatin and transcriptional regulation by reversible RNA methylation.
Academic Article	N6 -methyladenosine modification of lncRNA Pvt1 governs epidermal stemness.
Academic Article	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Academic Article	Transcriptome-Wide Detection of Internal N7-Methylguanosine.
Academic Article	ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Academic Article	N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.
Academic Article	METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article	The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
Academic Article	m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.
Academic Article	FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
Academic Article	Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA.
Academic Article	Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution.
Academic Article	m7G-quant-seq: Quantitative Detection of RNA Internal N7-Methylguanosine.
Academic Article	Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing.
Academic Article	Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination.
Academic Article	Exon architecture controls mRNA m6A suppression and gene expression.
Academic Article	BID-seq: The Quantitative and Base-Resolution Sequencing Method for RNA Pseudouridine.
Academic Article	The mechanism underlying redundant functions of the YTHDF proteins.
Academic Article	m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Academic Article	Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.
Academic Article	Mammalian DNA N6-methyladenosine: Challenges and new insights.
Concept	RNA Recognition Motif Proteins
Concept	AlkB Homolog 5, RNA Demethylase
Concept	RNA Splicing Factors
Concept	RNA, Long Noncoding
Grant	Discovering the epigenetics of RNA modifications
Grant	RNA methylation and regulatory T cells
Grant	Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant	Recognition and mechanism of N6-methyl adenosine modifications
Grant	Direct Oxidative Nucleic Acids Demethylation
Grant	Center for dynamic RNA epitranscriptomes - Renewal
Grant	Base-resolution sequencing of m6A in RNA
Grant	Direct Oxidative Nucleic Acids Demethylation
Academic Article	Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Academic Article	Advances in targeting RNA modifications for anticancer therapy.
Academic Article	Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease.
Academic Article	METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
Academic Article	Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Academic Article	YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
Academic Article	PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article	PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article	RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation.
Academic Article	Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Academic Article	Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA.
Academic Article	BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution.
Academic Article	FMRP phosphorylation modulates neuronal translation through YTHDF1.
Academic Article	Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications.
Academic Article	Author Correction: Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article	Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article	RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
Academic Article	mRNA accessibility within mRNPs as a determinant of gene expression.
Academic Article	Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA.
Academic Article	Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing.
Academic Article	Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
Academic Article	KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
Academic Article	m6A RNA methylation regulates mitochondrial function.
Academic Article	Chemical manipulation of m1A mediates its detection in human tRNA.
Academic Article	New horizons of regulatory RNA.
Academic Article	The YTHDF proteins display distinct cellular functions on m6A-modified RNA.
Academic Article	Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis.
Academic Article	LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA.
Academic Article	Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation.
Grant	Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation
Academic Article	RNA interacts with topoisomerase I to adjust DNA topology.
Academic Article	YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges.
Academic Article	IGF2BP3 promotes mRNA degradation through internal m7G modification.
Academic Article	YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
Academic Article	RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis.
Academic Article	Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency.
Academic Article	snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
Academic Article	N6-methyladenosine reader YTHDF2 in cell state transition and antitumor immunity.
Academic Article	Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation.
Academic Article	Author Correction: Quantitative RNA pseudouridine maps reveal multilayered translation control through plant rRNA, tRNA and mRNA pseudouridylation.
Academic Article	Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA.
Academic Article	YTHDFs as radiotherapy checkpoints in tumor immunity.

Search Criteria

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cytosine
methylation
RNA
m5C