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He, Chuan
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overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
One or more keywords matched the following items that are connected to He, Chuan
Item TypeName
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, Regulator
Concept Genes, Bacterial
Concept Oncogenes
Concept Multigene Family
Concept Models, Molecular
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Nucleic Acid Conformation
Concept Operon
Concept Genome
Concept Sequence Homology, Amino Acid
Concept Gene Library
Concept RNA Splice Sites
Concept Cell Adhesion Molecules
Concept Genes, Tumor Suppressor
Concept Genome, Bacterial
Concept Genome, Viral
Concept Molecular Conformation
Concept Genes, Reporter
Concept Consensus Sequence
Concept Genes, Plant
Concept Evolution, Molecular
Concept Molecular Chaperones
Concept Histone Code
Concept Catalytic Domain
Concept Molecular Targeted Therapy
Concept Regulatory Elements, Transcriptional
Concept Molecular Imaging
Concept Molecular Structure
Concept Genome, Human
Concept Small Molecule Libraries
Concept Structural Homology, Protein
Concept DNA Repeat Expansion
Concept Transcriptome
Concept Molecular Sequence Annotation
Concept Cloning, Molecular
Concept DNA, Single-Stranded
Concept Epistasis, Genetic
Concept Conserved Sequence
Concept Regulon
Concept Polymorphism, Single Nucleotide
Concept Quantitative Trait Loci
Concept Cystine Knot Motifs
Concept Molecular Dynamics Simulation
Concept Nucleotide Motifs
Academic Article Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691.
Academic Article Intramolecular amide bonds stabilize pili on the surface of bacilli.
Academic Article Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
Academic Article A selective fluorescent probe for carbon monoxide imaging in living cells.
Academic Article Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus.
Academic Article The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article The structure of the human AGT protein bound to DNA and its implications for damage detection.
Academic Article A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.
Academic Article Binding of ReO4(-) with an engineered MoO4(2-)-binding protein: towards a new approach in radiopharmaceutical applications.
Academic Article Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Academic Article Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism.
Academic Article Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.
Academic Article Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
Academic Article Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).
Academic Article Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article A diazirine-based nucleoside analogue for efficient DNA interstrand photocross-linking.
Academic Article Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine.
Academic Article Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.
Academic Article A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.
Academic Article Silver-catalyzed intermolecular amination of C--H groups.
Academic Article TET family proteins: oxidation activity, interacting molecules, and functions in diseases.
Academic Article Chemical methods to study protein-nucleic acid interactions.
Academic Article Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article Crystal structures of SlyA protein, a master virulence regulator of Salmonella, in free and DNA-bound states.
Academic Article Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking.
Academic Article Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article Diazirine-based DNA photo-cross-linking probes for the study of protein-DNA interactions.
Academic Article Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Academic Article Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Academic Article Selective recognition of metal ions by metalloregulatory proteins.
Academic Article Direct reversal of DNA alkylation damage.
Academic Article Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Academic Article Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2.
Academic Article Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article Gold-catalyzed organic transformations.
Academic Article Synthesis of a FTO inhibitor with anticonvulsant activity.
Academic Article Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Academic Article Modeling non-heme iron proteins.
Academic Article Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
Academic Article A protein engineered to bind uranyl selectively and with femtomolar affinity.
Academic Article Selective recognition of americium by peptide-based reagents.
Academic Article RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article Efficient and quantitative high-throughput tRNA sequencing.
Academic Article Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Academic Article Evolution of transcript modification by N6-methyladenosine in primates.
Academic Article Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Academic Article Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Academic Article Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article Author Correction: Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.
Academic Article Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II.
Academic Article KAS-seq: genome-wide sequencing of single-stranded DNA by N3-kethoxal-assisted labeling.
Academic Article m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.
Academic Article spKAS-seq reveals R-loop dynamics using low-input materials by detecting single-stranded DNA with strand specificity.
Academic Article Detection of m6A RNA modifications at single-nucleotide resolution using m6A-selective allyl chemical labeling and sequencing.
Academic Article Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Grant Discovering the epigenetics of RNA modifications
Grant RNA methylation and regulatory T cells
Grant Recognition and mechanism of N6-methyl adenosine modifications
Grant Predoctoral Training Program in Chemistry and Biology - Renewal 01
Grant Direct Oxidative Nucleic Acids Demethylation
Academic Article Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
Academic Article Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation.
Academic Article Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis.
Academic Article Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq.
Academic Article Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA.
Academic Article RNA modification systems as therapeutic targets.
Academic Article RNA modifications in cancer: from biological insights to therapeutic targets.
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