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One or more keywords matched the following properties of He, Chuan
overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
One or more keywords matched the following items that are connected to He, Chuan
Item TypeName
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, Regulator
Concept Gene Expression Regulation
Concept Genes, Bacterial
Concept Oncogenes
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Nucleic Acid Conformation
Concept Operon
Concept Genome
Concept Sequence Homology, Amino Acid
Concept Gene Rearrangement
Concept Gene Library
Concept RNA Splice Sites
Concept Up-Regulation
Concept Genes, Tumor Suppressor
Concept Genome, Bacterial
Concept Gene Expression
Concept Genes, Reporter
Concept Consensus Sequence
Concept Gene Deletion
Concept Gene Expression Regulation, Developmental
Concept Histone Code
Concept Catalytic Domain
Concept Gene Expression Profiling
Concept Regulatory Elements, Transcriptional
Concept Down-Regulation
Concept Molecular Structure
Concept Genome, Human
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Leukemic
Concept Gene Expression Regulation, Plant
Concept Gene Knockdown Techniques
Concept Gene Dosage
Concept Structural Homology, Protein
Concept Gene Fusion
Concept Transcriptome
Concept Epistasis, Genetic
Concept Gene Expression Regulation, Bacterial
Concept Gene Expression Regulation, Neoplastic
Concept Conserved Sequence
Concept Regulon
Concept Polymorphism, Single Nucleotide
Concept Quantitative Trait Loci
Concept Cystine Knot Motifs
Concept Nucleotide Motifs
Academic Article The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Academic Article A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.
Academic Article Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article Unique features of the m6A methylome in Arabidopsis thaliana.
Academic Article N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Academic Article Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article Dynamic RNA modifications in posttranscriptional regulation.
Academic Article Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.
Academic Article Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Academic Article Reversible RNA adenosine methylation in biological regulation.
Academic Article Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
Academic Article Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Academic Article N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Academic Article RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article Efficient and quantitative high-throughput tRNA sequencing.
Academic Article Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article RNA epigenetics--chemical messages for posttranscriptional gene regulation.
Academic Article Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Academic Article A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article Post-transcriptional gene regulation by mRNA modifications.
Academic Article The emerging biology of RNA post-transcriptional modifications.
Academic Article DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article Dynamic RNA Modifications in Gene Expression Regulation.
Academic Article Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article Chemical Modifications in the Life of an mRNA Transcript.
Academic Article RNA modifications modulate gene expression during development.
Academic Article RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Academic Article m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article Identifying the m6A Methylome by Affinity Purification and Sequencing.
Academic Article YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.
Academic Article Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
Academic Article Publisher Correction: Post-transcriptional gene regulation by mRNA modifications.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Grant Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Grant Mechanisms of Pancreatic Cancer Inhibition by SPARC
Academic Article Special Issue on Regulating the Central Dogma.
Academic Article Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article Regulation of Gene Expression by N6-methyladenosine in Cancer.
Academic Article METTL14 is essential for ß-cell survival and insulin secretion.
Academic Article Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.
Academic Article Detailed modeling of positive selection improves detection of cancer driver genes.
Academic Article Site-specific m6A editing.
Academic Article Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Academic Article N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m6A Methyltransferase Component METTL14 in T Cells.
Academic Article N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Academic Article A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article Chromatin and transcriptional regulation by reversible RNA methylation.
Academic Article Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Academic Article Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II.
Academic Article Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
Academic Article Identification and functional analysis of a novel mutation in the SOX10 gene associated with Waardenburg syndrome type IV.
Academic Article METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
Academic Article Exon architecture controls mRNA m6A suppression and gene expression.
Academic Article m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Concept Gene Editing
Concept Gene Ontology
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Grant Discovering the epigenetics of RNA modifications
Grant RNA methylation and regulatory T cells
Grant Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant Recognition and mechanism of N6-methyl adenosine modifications
Grant Global Cysteine Modifications in Human Pathogens
Grant Direct Oxidative Nucleic Acids Demethylation
Grant Base-resolution sequencing of m6A in RNA
Grant Direct Oxidative Nucleic Acids Demethylation
Academic Article Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Academic Article Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Academic Article YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
Academic Article BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution.
Academic Article Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article mRNA accessibility within mRNPs as a determinant of gene expression.
Academic Article 5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.
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  • gene
  • regulation