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He, Chuan

One or more keywords matched the following properties of He, Chuan

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overview	Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

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overview

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.

One or more keywords matched the following items that are connected to He, Chuan

Item Type	Name
Concept	Amino Acid Sequence
Concept	Base Sequence
Concept	Genes, Regulator
Concept	Gene Expression Regulation
Concept	Genes, Bacterial
Concept	Oncogenes
Concept	Molecular Sequence Data
Concept	Repetitive Sequences, Nucleic Acid
Concept	Nucleic Acid Conformation
Concept	Operon
Concept	Genome
Concept	Sequence Homology, Amino Acid
Concept	Gene Rearrangement
Concept	Gene Library
Concept	RNA Splice Sites
Concept	Up-Regulation
Concept	Genes, Tumor Suppressor
Concept	Genome, Bacterial
Concept	Gene Expression
Concept	Genes, Reporter
Concept	Consensus Sequence
Concept	Gene Deletion
Concept	Gene Expression Regulation, Developmental
Concept	Histone Code
Concept	Catalytic Domain
Concept	Gene Expression Profiling
Concept	Regulatory Elements, Transcriptional
Concept	Down-Regulation
Concept	Molecular Structure
Concept	Genome, Human
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Regulation, Leukemic
Concept	Gene Expression Regulation, Plant
Concept	Gene Knockdown Techniques
Concept	Gene Dosage
Concept	Structural Homology, Protein
Concept	Gene Fusion
Concept	Transcriptome
Concept	Epistasis, Genetic
Concept	Gene Expression Regulation, Bacterial
Concept	Gene Expression Regulation, Neoplastic
Concept	Conserved Sequence
Concept	Regulon
Concept	Polymorphism, Single Nucleotide
Concept	Quantitative Trait Loci
Concept	Cystine Knot Motifs
Concept	Nucleotide Motifs
Academic Article	The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis.
Academic Article	Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.
Academic Article	A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.
Academic Article	Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus.
Academic Article	Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article	Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article	HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article	TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article	Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Academic Article	Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article	Unique features of the m6A methylome in Arabidopsis thaliana.
Academic Article	N6-methyladenosine-dependent regulation of messenger RNA stability.
Academic Article	ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Academic Article	Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article	Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article	Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae.
Academic Article	Dynamic RNA modifications in posttranscriptional regulation.
Academic Article	Aureusimines in Staphylococcus aureus are not involved in virulence.
Academic Article	N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article	The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Academic Article	A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.
Academic Article	Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA.
Academic Article	Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
Academic Article	Reversible RNA adenosine methylation in biological regulation.
Academic Article	Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
Academic Article	Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article	Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article	Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Academic Article	N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Academic Article	RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article	Efficient and quantitative high-throughput tRNA sequencing.
Academic Article	Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article	RNA epigenetics--chemical messages for posttranscriptional gene regulation.
Academic Article	Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article	Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article	Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus.
Academic Article	A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article	ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article	Post-transcriptional gene regulation by mRNA modifications.
Academic Article	The emerging biology of RNA post-transcriptional modifications.
Academic Article	DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article	Dynamic RNA Modifications in Gene Expression Regulation.
Academic Article	Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article	Chemical Modifications in the Life of an mRNA Transcript.
Academic Article	RNA modifications modulate gene expression during development.
Academic Article	RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article	Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Academic Article	m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article	Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article	Identifying the m6A Methylome by Affinity Purification and Sequencing.
Academic Article	YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.
Academic Article	Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
Academic Article	Publisher Correction: Post-transcriptional gene regulation by mRNA modifications.
Academic Article	Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Grant	Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Grant	Mechanisms of Pancreatic Cancer Inhibition by SPARC
Academic Article	Special Issue on Regulating the Central Dogma.
Academic Article	Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article	Regulation of Gene Expression by N6-methyladenosine in Cancer.
Academic Article	METTL14 is essential for ß-cell survival and insulin secretion.
Academic Article	Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article	FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export.
Academic Article	Detailed modeling of positive selection improves detection of cancer driver genes.
Academic Article	Site-specific m6A editing.
Academic Article	Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG.
Academic Article	N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article	Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ.
Academic Article	A New Model of Spontaneous Colitis in Mice Induced by Deletion of an RNA m6A Methyltransferase Component METTL14 in T Cells.
Academic Article	N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Academic Article	A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article	Chromatin and transcriptional regulation by reversible RNA methylation.
Academic Article	Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Academic Article	Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II.
Academic Article	Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
Academic Article	Identification and functional analysis of a novel mutation in the SOX10 gene associated with Waardenburg syndrome type IV.
Academic Article	METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article	FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
Academic Article	Exon architecture controls mRNA m6A suppression and gene expression.
Academic Article	m6A-SAC-seq for quantitative whole transcriptome m6A profiling.
Concept	Gene Editing
Concept	Gene Ontology
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Grant	Discovering the epigenetics of RNA modifications
Grant	RNA methylation and regulatory T cells
Grant	Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant	Recognition and mechanism of N6-methyl adenosine modifications
Grant	Global Cysteine Modifications in Human Pathogens
Grant	Direct Oxidative Nucleic Acids Demethylation
Grant	Base-resolution sequencing of m6A in RNA
Grant	Direct Oxidative Nucleic Acids Demethylation
Academic Article	Splice epitranscriptomics and DNA damage repair together: ALKBH5-m6A-SF3B1 regulation in leukemic transformation.
Academic Article	Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Academic Article	YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
Academic Article	BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution.
Academic Article	Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article	mRNA accessibility within mRNPs as a determinant of gene expression.
Academic Article	5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma.
Academic Article	Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation.
Academic Article	Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis.
Grant	Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation
Academic Article	Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures.
Academic Article	Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq.
Academic Article	IGF2BP3 promotes mRNA degradation through internal m7G modification.

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