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overview Saygin Lab studies leukemia biology by using in vitro and in vivo models of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), as well as human samples obtained from patients with leukemia. We are particularly interested in drivers of CHIP (clonal hematopoiesis of indeterminate potential) progression to leukemias of myeloid vs lymphoid lineage in de novo and therapy-related leukemogenesis. Our translational research lab aims to identify mechanisms driving these fatal diseases and leverage them for new experimental therapeutics. Our drug development efforts focusing on high-risk subsets of AML and ALL have led to “home-grown” phase I/II investigator-initiated clinical trials.
One or more keywords matched the following items that are connected to Saygin, Caner
Item TypeName
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Academic Article Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Academic Article Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients.
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.
Academic Article Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Academic Article A 17-year experience with ALL-BFM protocol in acute lymphoblastic leukemia: prognostic predictors and interruptions during protocol.
Academic Article Prognostic impact of incomplete hematologic count recovery and minimal residual disease on outcome in adult acute lymphoblastic leukemia at the time of second complete response.
Academic Article Outcomes of the cyclophosphamide, vincristine, prednisone (CVP) +/- rituximab (R-CVP) regimen in older patients with newly diagnosed Ph- acute lymphoblastic leukemia.
Academic Article Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.
Academic Article Durable responses in acute lymphoblastic leukaemia with the use of FLT3 and IDH inhibitors.
Academic Article Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis.
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
Academic Article Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia.
Academic Article Acute Lymphoblastic Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.
Academic Article Venetoclax in combination with a pediatric-inspired regimen for the treatment of newly diagnosed adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.
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  • Acute Lymphoblastic Leukemia