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One or more keywords matched the following properties of Saygin, Caner
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keywords acute leukemia
overview Saygin Lab studies leukemia biology by using in vitro and in vivo models of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), as well as human samples obtained from patients with leukemia. We are particularly interested in drivers of CHIP (clonal hematopoiesis of indeterminate potential) progression to leukemias of myeloid vs lymphoid lineage in de novo and therapy-related leukemogenesis. Our translational research lab aims to identify mechanisms driving these fatal diseases and leverage them for new experimental therapeutics. Our drug development efforts focusing on high-risk subsets of AML and ALL have led to “home-grown” phase I/II investigator-initiated clinical trials.
One or more keywords matched the following items that are connected to Saygin, Caner
Item TypeName
Concept Leukemia
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Leukemia, Myeloid
Concept Leukemia, Myeloid, Acute
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Leukemia, Myelomonocytic, Chronic
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Academic Article Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Academic Article OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia.
Academic Article Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies.
Academic Article B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas.
Academic Article Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients.
Concept Myeloid Cell Leukemia Sequence 1 Protein
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.
Academic Article Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Academic Article LC-FACSeq is a method for detecting rare clones in leukemia.
Academic Article Emerging therapies for acute myeloid leukemia.
Academic Article A 17-year experience with ALL-BFM protocol in acute lymphoblastic leukemia: prognostic predictors and interruptions during protocol.
Academic Article The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.
Academic Article Type of prior genotoxic insult determines the genomic characteristics of therapy-related myeloid neoplasms.
Academic Article Genomic determinants of chronic myelomonocytic leukemia.
Academic Article Prognostic impact of incomplete hematologic count recovery and minimal residual disease on outcome in adult acute lymphoblastic leukemia at the time of second complete response.
Academic Article Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1.
Academic Article Outcomes of the cyclophosphamide, vincristine, prednisone (CVP) +/- rituximab (R-CVP) regimen in older patients with newly diagnosed Ph- acute lymphoblastic leukemia.
Academic Article Correction: Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Academic Article A phase I study of lenalidomide plus chemotherapy with idarubicin and cytarabine in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome.
Academic Article Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Academic Article Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748.
Academic Article Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.
Academic Article Durable responses in acute lymphoblastic leukaemia with the use of FLT3 and IDH inhibitors.
Academic Article Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis.
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
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  • Leukemia