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Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Structure and mechanism of the ER-based glucosyltransferase ALG6.
Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Structures of ABCB4 provide insight into phosphatidylcholine translocation.
Structure of an AMPK complex in an inactive, ATP-bound state.
Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Architecture of the cytoplasmic face of the nuclear pore.
A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Cryo electron Microscopy