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One or more keywords matched the following properties of Kossiakoff, Anthony
keywords Structural Biology
overview The Kossiakoff Group's research interests are to provide a molecular understanding of how molecular recognition governs virtually all aspects of biological function. To study these issues our group employs a combination of X-ray crystallography and cryo-EM, site-directed mutagenesis, phage display and biophysical analysis. The Kossiakoff group has also pioneered a new technology called “chaperone-assisted” crystallography, which has facilitated the structural analyses of protein systems that had been totally recalcitrant to other approaches. The group has also been at the forefront of developing synthetic antibodies. These synthetic antibodies are much more powerful that traditional monoclonal antibodies and have the potential to completely replace them for uses in live cell imaging and proteomics.
One or more keywords matched the following items that are connected to Kossiakoff, Anthony
Item TypeName
Concept Models, Structural
Concept Structural Homology, Protein
Concept Computational Biology
Academic Article Structural consequences of mutation.
Academic Article Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor.
Academic Article Structural basis for cytokine hormone-receptor recognition and receptor activation.
Academic Article The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A.
Academic Article Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article Neutron protein crystallography: advances in methods and applications.
Academic Article Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis.
Academic Article The use of neutrons to show how proteins work.
Academic Article The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation.
Academic Article Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Academic Article Cell biology. New tricks for an old dimer.
Academic Article Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Academic Article Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
Academic Article Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Academic Article Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Academic Article Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Award or Honor Receipt Chair Department of Biochemistry and Molecular Biology
Academic Article Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Academic Article Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
Academic Article Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
Grant Chaperone Assisted Crystallography
Grant Chaperone-Enabled studies of epigenetic regulation enzymes
Grant Energetics of cytokine-induced receptor signaling
Academic Article Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Academic Article Structural and molecular basis of choline uptake into the brain by FLVCR2.
Academic Article Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains.
Academic Article Structural and molecular basis of choline uptake into the brain by FLVCR2.
Academic Article Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Academic Article Structural Insights into the Roles of PARP4 and NAD + in the Human Vault Cage.
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