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Staley, Jonathan P.
One or more keywords matched the following properties of Staley, Jonathan P.
PropertyValue
keywords Spliceosome
overview Our goal is to understand the mechanism and regulation of nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive multimegadalton ribonucleoprotein machine called the spliceosome. Using the model organism S. cerevisiae as well as human cells, we apply a wide array of approaches, ranging from single molecule microscopy, biophysics, and chemical biology to biochemistry and cell biology to genetics and genomics to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing, including in the context of transcription.
One or more keywords matched the following items that are connected to Staley, Jonathan P.
Item TypeName
Concept RNA Splice Sites
Concept Spliceosomes
Academic Article Mechanical devices of the spliceosome: motors, clocks, springs, and things.
Academic Article An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
Academic Article Hanging on to the branch.
Academic Article U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.
Academic Article A role for ubiquitin in the spliceosome assembly pathway.
Academic Article Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines.
Academic Article Long-distance splicing.
Academic Article The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.
Academic Article Spliceosome discards intermediates via the DEAH box ATPase Prp43p.
Academic Article Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!
Academic Article The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.
Academic Article Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast.
Academic Article Splicing fidelity: DEAD/H-box ATPases as molecular clocks.
Academic Article RNA catalyses nuclear pre-mRNA splicing.
Academic Article The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.
Academic Article Evidence for a group II intron-like catalytic triplex in the spliceosome.
Academic Article Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.
Academic Article Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.
Academic Article Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6.
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  • splicing