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overview Dr. Anthony Reder has a 30-year interest in multiple sclerosis. He has coauthored over 150 papers, plus abstracts and presentations, on multiple sclerosis and animal models of MS. His primary research interests are in the interaction between the central nervous system (CNS) and the cellular immune system, and in how the brain and immune system are altered by the drugs we use to treat MS. Professor Reder has an active lab studying many facets of the immune disruption in MS, and also the mechanism of action of interferon-beta, the most widely-used treatment for MS. They have recently found that there is a defect in the interferon signaling pathway in lymphocytes from progressive forms of MS. This may be why some patients with progressive MS do not respond clinically to interferon therapy. Dr. Reder and other faculty members at the University of Chicago have participated in the development of multiple new treatments for MS. These include the first biological therapy for MS, interferon-beta, plus other drugs including glatiramer (Copaxone), natalizumab (Tysabri), rituximab, ocrelizumab, estriol (the pregnancy hormone), and FTY720/fingolimod (Gilenya), plus drugs for pain in MS such as misoprostol. He has also evaluated IFN-? patients 21 years after the original pivotal trial, the effects of statins and vitamin D on IFN efficacy, Current clinical trials include promising new drugs for neuromyelitis optica (NMO) and progressive MS. He has trained a number of excellent MS fellows, funded by the US National MS Society. Prior fellows, Adil Javed, and as of Aug 1, Veronica Cipriani, are now on faculty at the U of Chicago. Dr. Javed defined a new variant of MS, CNS Sjögren’s disease, which requires different treatments than conventional MS. Dr. Reder is also kind to puppies.

One or more keywords matched the following items that are connected to Reder, Anthony T.

Item TypeName
Concept Multiple Sclerosis
Concept Multiple Sclerosis, Relapsing-Remitting
Concept Multiple Sclerosis, Chronic Progressive
Academic Article T cell lymphokine-induced secretion of cytokines by monocytes from patients with multiple sclerosis.
Academic Article Increased high affinity beta-adrenergic receptor densities and cyclic AMP responses of CD8 cells in multiple sclerosis.
Academic Article Serum prolactin levels in active multiple sclerosis and during cyclosporin treatment.
Academic Article Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.
Academic Article Mechanisms of action of interferon-beta in multiple sclerosis.
Academic Article Validation of the functional assessment of multiple sclerosis quality of life instrument.
Academic Article The mast cells of the multiple sclerosis brain.
Academic Article Improved delayed visual reproduction test performance in multiple sclerosis patients receiving interferon beta-1b.
Academic Article Effects of an anti-IL-10 monoclonal antibody on rIFNbeta-1b-mediated immune modulation. Relevance to multiple sclerosis.
Academic Article Interferon beta-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis.
Academic Article Interferon-beta treatment does not elevate cortisol in multiple sclerosis.
Academic Article Increased lymphocyte beta-adrenergic receptor density in progressive multiple sclerosis is specific for the CD8+, CD28- suppressor cell.
Academic Article Monocyte activation in multiple sclerosis.
Academic Article Injecting rationale into interferon-beta therapy.
Academic Article Three-dimensional human pattern visual evoked potentials. II. Multiple sclerosis patients.
Academic Article Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis.
Academic Article Psychometric evaluation of the Chicago Multiscale Depression Inventory in multiple sclerosis patients.
Academic Article Internal capsule plaque and tonic spasms in multiple sclerosis.
Academic Article Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis.
Academic Article Interferon-beta regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis.
Academic Article Therapeutic role of beta-interferons in multiple sclerosis.
Academic Article IFN-beta-regulated genes show abnormal expression in therapy-naïve relapsing-remitting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions.
Academic Article Anti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
Academic Article Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis.
Academic Article 4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis.
Academic Article Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis.
Academic Article Long-term follow-up of the original interferon-beta1b trial in multiple sclerosis: design and lessons from a 16-year observational study.
Academic Article Sympathetic skin responses are decreased and lymphocyte beta-adrenergic receptors are increased in progressive multiple sclerosis.
Academic Article Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial.
Academic Article Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis.
Academic Article Neuroendocrine regulation and the immune response in MS.
Academic Article Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis.
Academic Article MxA: a biomarker for predicting multiple sclerosis disease activity.
Academic Article Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis.
Academic Article Fingolimod for the treatment of relapsing multiple sclerosis.
Academic Article Evidence-based medicine: promise and pitfalls.
Academic Article Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
Academic Article Molecular analysis of the CD8 gene in multiple sclerosis.
Academic Article ACTH production by human mononuclear cells.
Academic Article Immunoregulation in rapidly progressive multiple sclerosis.
Academic Article IFN-beta1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression.
Academic Article Multiple sclerosis: relation of in vitro IgG secretion to T suppressor cell number and function.
Academic Article Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients.
Academic Article Increased muscarinic cholinergic receptor density on CD4+ lymphocytes in progressive multiple sclerosis.
Academic Article Recognizing and treating suboptimally controlled multiple sclerosis: steps toward regaining command.
Academic Article Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b.
Academic Article Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon ß-1b trial in multiple sclerosis.
Academic Article Activated suppressor cell dysfunction in progressive multiple sclerosis.
Academic Article Activated suppressor cell function in multiple sclerosis--clinical correlations.
Academic Article Clinical spectrum of multiple sclerosis.
Academic Article B-cell differentiation in multiple sclerosis and the effect of intravenous ACTH.
Academic Article Comparison of T8+ cell-mediated suppressor and cytotoxic functions in multiple sclerosis.
Academic Article Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNß-1b trial.
Academic Article Trigeminal neuralgia in multiple sclerosis relieved by a prostaglandin E analogue.
Academic Article IFN-gamma, IFN-beta, and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis.
Academic Article T regulator cell surface antigens in multiple sclerosis.
Academic Article Analysis of T regulator cell surface markers and functional properties in multiple sclerosis.
Academic Article Immunoregulation in multiple sclerosis.
Academic Article Response to GS Gronseth and E Ashman.
Academic Article Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Academic Article Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS.
Academic Article Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis.
Academic Article Blood lymphocyte beta-adrenergic receptors in multiple sclerosis.
Academic Article Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2.
Academic Article Dexamethasone suppression test abnormalities in multiple sclerosis: relation to ACTH therapy.
Academic Article Low T8 antigen density on lymphocytes in active multiple sclerosis.
Academic Article The function of the CD2 protein is abnormal in multiple sclerosis.
Academic Article Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.
Academic Article Soluble CD8 levels in the CSF and serum of patients with multiple sclerosis.
Academic Article Abnormal levels of interferon-gamma receptors in active multiple sclerosis are normalized by IFN-beta therapy: implications for control of apoptosis.
Academic Article Adrenal size is increased in multiple sclerosis.
Academic Article Multiple sclerosis. Part I: neuro-ophthalmic manifestations.
Academic Article Establishing long-term efficacy in chronic disease: use of recursive partitioning and propensity score adjustment to estimate outcome in MS.
Academic Article Treatment with interferon beta for multiple sclerosis.
Academic Article Urinary myelin basic protein-like material as a correlate of the progression of multiple sclerosis.
Academic Article Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).
Academic Article Brief International Cognitive Assessment for MS (BICAMS): international standards for validation.
Academic Article Cystoid macular edema associated with fingolimod use for multiple sclerosis.
Academic Article Ophthalmic evaluations in clinical studies of fingolimod (FTY720) in multiple sclerosis.
Academic Article Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins.
Academic Article The effects of long-term interferon-beta-1b treatment on cognitive functioning in multiple sclerosis: a 16-year longitudinal study.
Academic Article How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms.
Academic Article Induction of a unique isoform of the NCOA7 oxidation resistance gene by interferon ß-1b.
Academic Article Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.
Academic Article Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis.
Academic Article Short-term and long-term safety and tolerability of interferon ß-1b in multiple sclerosis.
Academic Article Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial.
Academic Article First-dose effects of fingolimod: Pooled safety data from three phase 3 studies.
Academic Article Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Academic Article Patient Preferences for Injectable Treatments for Multiple Sclerosis in the United States: A Discrete-Choice Experiment.
Academic Article The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis.
Academic Article Relapses in multiple sclerosis: Relationship to disability.
Academic Article Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature.
Academic Article Vitamin D and Multiple Sclerosis: A Comprehensive Review.
Academic Article Predictive validity of NEDA in the 16- and 21-year follow-up from the pivotal trial of interferon beta-1b.
Academic Article Early MRI results and odds of attaining 'no evidence of disease activity' status in MS patients treated with interferon ß-1a in the EVIDENCE study.
Academic Article Gray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.
Academic Article Dimethyl fumarate-induced changes in the MS lymphocyte repertoire: No need for subset monitoring.
Academic Article Vitamin D enhances responses to interferon-ß in MS.
Academic Article Interferon-ß corrects massive gene dysregulation in multiple sclerosis: Short-term and long-term effects on immune regulation and neuroprotection.
Academic Article Thoracic flexion provokes circumferential dysesthesia: A symptom of thoracic cord lesions in MS.
Academic Article Disability improvement as a clinically relevant outcome in clinical trials of relapsing forms of multiple sclerosis.
Academic Article COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
Academic Article Anti-CD20 therapy corrects a CD8 regulatory T cell deficit in multiple sclerosis.
Academic Article Real-world propensity score comparison of treatment effectiveness of peginterferon beta-1a vs. subcutaneous interferon beta-1a, glatiramer acetate, and teriflunomide in patients with relapsing-remitting multiple sclerosis.
Academic Article Interferons and Multiple Sclerosis: Lessons from 25 Years of Clinical and Real-World Experience with Intramuscular Interferon Beta-1a (Avonex).
Academic Article Ocrelizumab treatment for relapsing-remitting multiple sclerosis after a suboptimal response to previous disease-modifying therapy: A nonrandomized controlled trial.
Academic Article Medications for Multiple Sclerosis and Risk of Malignancy: What Next?

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