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Reder, Anthony T.

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overview	Dr. Anthony Reder has a 30-year interest in multiple sclerosis. He has coauthored over 150 papers, plus abstracts and presentations, on multiple sclerosis and animal models of MS. His primary research interests are in the interaction between the central nervous system (CNS) and the cellular immune system, and in how the brain and immune system are altered by the drugs we use to treat MS. Professor Reder has an active lab studying many facets of the immune disruption in MS, and also the mechanism of action of interferon-beta, the most widely-used treatment for MS. They have recently found that there is a defect in the interferon signaling pathway in lymphocytes from progressive forms of MS. This may be why some patients with progressive MS do not respond clinically to interferon therapy. Dr. Reder and other faculty members at the University of Chicago have participated in the development of multiple new treatments for MS. These include the first biological therapy for MS, interferon-beta, plus other drugs including glatiramer (Copaxone), natalizumab (Tysabri), rituximab, ocrelizumab, estriol (the pregnancy hormone), and FTY720/fingolimod (Gilenya), plus drugs for pain in MS such as misoprostol. He has also evaluated IFN-? patients 21 years after the original pivotal trial, the effects of statins and vitamin D on IFN efficacy, Current clinical trials include promising new drugs for neuromyelitis optica (NMO) and progressive MS. He has trained a number of excellent MS fellows, funded by the US National MS Society. Prior fellows, Adil Javed, and as of Aug 1, Veronica Cipriani, are now on faculty at the U of Chicago. Dr. Javed defined a new variant of MS, CNS Sjögren’s disease, which requires different treatments than conventional MS. Dr. Reder is also kind to puppies.

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Value

overview

Dr. Anthony Reder has a 30-year interest in multiple sclerosis. He has coauthored over 150 papers, plus abstracts and presentations, on multiple sclerosis and animal models of MS. His primary research interests are in the interaction between the central nervous system (CNS) and the cellular immune system, and in how the brain and immune system are altered by the drugs we use to treat MS. Professor Reder has an active lab studying many facets of the immune disruption in MS, and also the mechanism of action of interferon-beta, the most widely-used treatment for MS. They have recently found that there is a defect in the interferon signaling pathway in lymphocytes from progressive forms of MS. This may be why some patients with progressive MS do not respond clinically to interferon therapy. Dr. Reder and other faculty members at the University of Chicago have participated in the development of multiple new treatments for MS. These include the first biological therapy for MS, interferon-beta, plus other drugs including glatiramer (Copaxone), natalizumab (Tysabri), rituximab, ocrelizumab, estriol (the pregnancy hormone), and FTY720/fingolimod (Gilenya), plus drugs for pain in MS such as misoprostol. He has also evaluated IFN-? patients 21 years after the original pivotal trial, the effects of statins and vitamin D on IFN efficacy, Current clinical trials include promising new drugs for neuromyelitis optica (NMO) and progressive MS. He has trained a number of excellent MS fellows, funded by the US National MS Society. Prior fellows, Adil Javed, and as of Aug 1, Veronica Cipriani, are now on faculty at the U of Chicago. Dr. Javed defined a new variant of MS, CNS Sjögren’s disease, which requires different treatments than conventional MS. Dr. Reder is also kind to puppies.

One or more keywords matched the following items that are connected to Reder, Anthony T.

Item Type	Name
Concept	Amyotrophic Lateral Sclerosis
Concept	Alleles
Concept	Amino Acid Sequence
Concept	Antigens, Surface
Concept	Antibody Specificity
Concept	Behavioral Symptoms
Concept	Electric Stimulation
Concept	Cell Separation
Concept	Brain Stem
Concept	Central Nervous System
Concept	Evaluation Studies as Topic
Concept	Sleep Initiation and Maintenance Disorders
Concept	Cross-Sectional Studies
Concept	Disease Susceptibility
Concept	Munchausen Syndrome
Concept	Genes
Concept	Neurosecretory Systems
Concept	Product Surveillance, Postmarketing
Concept	Organ Size
Concept	Molecular Sequence Data
Concept	Nervous System Diseases
Concept	Safety
Concept	Sjogren's Syndrome
Concept	Stimulation, Chemical
Concept	Receptors, Cell Surface
Concept	Sensation
Concept	Sequence Homology, Nucleic Acid
Concept	Species Specificity
Concept	Cohort Studies
Concept	Salivary Glands, Minor
Concept	Sensitivity and Specificity
Concept	Gonadal Steroid Hormones
Concept	Sheep
Concept	Skin
Concept	Suppressor Factors, Immunologic
Concept	Sympathetic Nervous System
Concept	United States
Concept	Lupus Erythematosus, Systemic
Concept	Multiple Sclerosis
Concept	Chi-Square Distribution
Concept	Seroepidemiologic Studies
Concept	Case-Control Studies
Concept	T-Lymphocyte Subsets
Concept	Alternative Splicing
Concept	Protein Structure, Tertiary
Concept	Genes, Reporter
Concept	Myelin Sheath
Concept	Oxidative Stress
Concept	Multiple Sclerosis, Relapsing-Remitting
Concept	Multiple Sclerosis, Chronic Progressive
Concept	Self Report
Concept	STAT Transcription Factors
Concept	Oligonucleotide Array Sequence Analysis
Concept	Surveys and Questionnaires
Concept	Rats, Inbred Strains
Concept	Serine
Concept	Severity of Illness Index
Concept	Scopolamine Derivatives
Concept	Secretory Rate
Concept	Submandibular Gland Diseases
Concept	Propensity Score
Concept	Sex Factors
Concept	Spinal Cord Diseases
Concept	Spleen
Concept	Staphylococcus aureus
Concept	Regulatory Elements, Transcriptional
Concept	Sympathectomy, Chemical
Concept	Survival Analysis
Concept	Open Reading Frames
Concept	2',5'-Oligoadenylate Synthetase
Concept	Lymphocyte Subsets
Concept	Validation Studies as Topic
Concept	STAT1 Transcription Factor
Concept	Transcriptome
Concept	Genome-Wide Association Study
Concept	Secondary Prevention
Concept	Drug Administration Schedule
Concept	Follow-Up Studies
Concept	Growth Substances
Concept	Health Status
Concept	Injections, Subcutaneous
Concept	Longitudinal Studies
Concept	Prostaglandins E, Synthetic
Concept	Retrospective Studies
Concept	Seizures
Concept	Self Administration
Concept	Serine Endopeptidases
Concept	Sphingosine
Concept	Spinal Cord
Concept	Signal Transduction
Concept	Polymorphism, Single Nucleotide
Concept	Macromolecular Substances
Concept	Stroop Test
Concept	Drug Substitution
Academic Article	MK-801 protects retinal neurons from hypoxia and the toxicity of glutamate and aspartate.
Academic Article	T cell lymphokine-induced secretion of cytokines by monocytes from patients with multiple sclerosis.
Academic Article	Increased high affinity beta-adrenergic receptor densities and cyclic AMP responses of CD8 cells in multiple sclerosis.
Academic Article	Serum prolactin levels in active multiple sclerosis and during cyclosporin treatment.
Academic Article	Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.
Academic Article	Mechanisms of action of interferon-beta in multiple sclerosis.
Academic Article	Validation of the functional assessment of multiple sclerosis quality of life instrument.
Academic Article	The mast cells of the multiple sclerosis brain.
Academic Article	Improved delayed visual reproduction test performance in multiple sclerosis patients receiving interferon beta-1b.
Academic Article	Effects of an anti-IL-10 monoclonal antibody on rIFNbeta-1b-mediated immune modulation. Relevance to multiple sclerosis.
Academic Article	Interferon beta-1b effects on cytokine mRNA in peripheral mononuclear cells in multiple sclerosis.
Academic Article	Severe tetanus in immunized patients with high anti-tetanus titers.
Academic Article	Interferon-beta treatment does not elevate cortisol in multiple sclerosis.
Academic Article	Increased lymphocyte beta-adrenergic receptor density in progressive multiple sclerosis is specific for the CD8+, CD28- suppressor cell.
Academic Article	Improved band resolution, loading reliability and reduced 32P contamination in mobility shift assays by retention of unbound probe.
Academic Article	Monocyte activation in multiple sclerosis.
Academic Article	Type I interferons inhibit interleukin-10 production in activated human monocytes and stimulate IL-10 in T cells: implications for Th1-mediated diseases.
Academic Article	Injecting rationale into interferon-beta therapy.
Academic Article	Three-dimensional human pattern visual evoked potentials. II. Multiple sclerosis patients.
Academic Article	Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
Academic Article	Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity.
Academic Article	Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing-remitting multiple sclerosis.
Academic Article	Psychometric evaluation of the Chicago Multiscale Depression Inventory in multiple sclerosis patients.
Academic Article	Internal capsule plaque and tonic spasms in multiple sclerosis.
Academic Article	Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis.
Academic Article	Interferon-beta regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis.
Academic Article	Therapeutic role of beta-interferons in multiple sclerosis.
Academic Article	IFN-beta-regulated genes show abnormal expression in therapy-naïve relapsing-remitting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions.
Academic Article	Anti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
Academic Article	Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis.
Academic Article	4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis.
Academic Article	Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis.
Academic Article	Minor salivary gland inflammation in Devic's disease and longitudinally extensive myelitis.
Academic Article	An epitope shared by central nervous system myelin and peripheral blood macrophages.
Academic Article	Long-term follow-up of the original interferon-beta1b trial in multiple sclerosis: design and lessons from a 16-year observational study.
Academic Article	The effect of chemical sympathectomy on natural killer cells in mice.
Academic Article	Sympathetic skin responses are decreased and lymphocyte beta-adrenergic receptors are increased in progressive multiple sclerosis.
Academic Article	Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial.
Academic Article	Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis.
Academic Article	Neuroendocrine regulation and the immune response in MS.
Academic Article	Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis.
Academic Article	MxA: a biomarker for predicting multiple sclerosis disease activity.
Academic Article	Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis.
Academic Article	Fingolimod for the treatment of relapsing multiple sclerosis.
Academic Article	Evidence-based medicine: promise and pitfalls.
Academic Article	Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
Academic Article	Molecular analysis of the CD8 gene in multiple sclerosis.
Academic Article	ACTH production by human mononuclear cells.
Academic Article	Immunoregulation in rapidly progressive multiple sclerosis.
Academic Article	IFN-beta1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression.
Academic Article	Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity.
Academic Article	Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test.
Academic Article	T cell regulation of polyclonally induced immunoglobulin secretion in humans.
Academic Article	Multiple sclerosis: relation of in vitro IgG secretion to T suppressor cell number and function.
Academic Article	Neurologic Munchausen's redux.
Academic Article	Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients.
Academic Article	Increased muscarinic cholinergic receptor density on CD4+ lymphocytes in progressive multiple sclerosis.
Academic Article	Recognizing and treating suboptimally controlled multiple sclerosis: steps toward regaining command.
Academic Article	Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b.
Academic Article	Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon ß-1b trial in multiple sclerosis.
Academic Article	Age-related changes in mechanisms accounting for low levels of polyclonally induced immunoglobulin secretion in humans.
Academic Article	Activated suppressor cell dysfunction in progressive multiple sclerosis.
Academic Article	Activated suppressor cell function in multiple sclerosis--clinical correlations.
Academic Article	Clinical spectrum of multiple sclerosis.
Academic Article	B-cell differentiation in multiple sclerosis and the effect of intravenous ACTH.
Academic Article	Senile dementia of Alzheimer's type (SDAT): reduced T8+-cell-mediated suppressor activity.
Academic Article	Comparison of T8+ cell-mediated suppressor and cytotoxic functions in multiple sclerosis.
Academic Article	Survival in MS: a randomized cohort study 21 years after the start of the pivotal IFNß-1b trial.
Academic Article	Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology.
Academic Article	Trigeminal neuralgia in multiple sclerosis relieved by a prostaglandin E analogue.
Academic Article	A reduction in serum glucocorticoids provokes experimental allergic encephalomyelitis: implications for treatment of inflammatory brain disease.
Academic Article	IFN-gamma, IFN-beta, and PGE1 affect monokine secretion: relevance to monocyte activation in multiple sclerosis.
Academic Article	T regulator cell surface antigens in multiple sclerosis.
Academic Article	Analysis of T regulator cell surface markers and functional properties in multiple sclerosis.
Academic Article	Immunoregulation in multiple sclerosis.
Academic Article	Epilepsy evoked by eating: the role of peripheral input.
Academic Article	Homonymous hemimacular thinning: a unique presentation of optic tract injury in neuromyelitis optica.
Academic Article	Clinical and genetic studies of fatal familial insomnia.
Academic Article	Response to GS Gronseth and E Ashman.
Academic Article	Astrocyte cytolysis by MHC class II-specific mouse T cell clones.
Academic Article	Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: relationship to the dexamethasone suppression test.
Academic Article	Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Academic Article	Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone.
Academic Article	Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS.
Academic Article	Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis.
Academic Article	Blood lymphocyte beta-adrenergic receptors in multiple sclerosis.
Academic Article	Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2.
Academic Article	Dexamethasone suppression test abnormalities in multiple sclerosis: relation to ACTH therapy.
Academic Article	Low T8 antigen density on lymphocytes in active multiple sclerosis.
Academic Article	The function of the CD2 protein is abnormal in multiple sclerosis.
Academic Article	Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.
Academic Article	Soluble CD8 levels in the CSF and serum of patients with multiple sclerosis.
Academic Article	Abnormal levels of interferon-gamma receptors in active multiple sclerosis are normalized by IFN-beta therapy: implications for control of apoptosis.
Academic Article	Adrenal size is increased in multiple sclerosis.
Academic Article	Multiple sclerosis. Part I: neuro-ophthalmic manifestations.
Academic Article	Interferonß-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling.
Academic Article	Establishing long-term efficacy in chronic disease: use of recursive partitioning and propensity score adjustment to estimate outcome in MS.
Academic Article	Treatment with interferon beta for multiple sclerosis.
Academic Article	Dissociation of T8+ cell-mediated cytolytic and suppressor functions in young adults.
Academic Article	Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis.
Academic Article	Urinary myelin basic protein-like material as a correlate of the progression of multiple sclerosis.
Academic Article	Neuroleukin: a lymphokine product of lectin-stimulated T cells.
Academic Article	Recommendations for a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).
Academic Article	Cause of death in MS: long-term follow-up of a randomised cohort, 21 years after the start of the pivotal IFNß-1b study.
Academic Article	Brief International Cognitive Assessment for MS (BICAMS): international standards for validation.
Academic Article	Cystoid macular edema associated with fingolimod use for multiple sclerosis.
Academic Article	Ophthalmic evaluations in clinical studies of fingolimod (FTY720) in multiple sclerosis.
Academic Article	Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins.
Academic Article	The effects of long-term interferon-beta-1b treatment on cognitive functioning in multiple sclerosis: a 16-year longitudinal study.
Academic Article	How type I interferons work in multiple sclerosis and other diseases: some unexpected mechanisms.
Academic Article	Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management.
Academic Article	Induction of a unique isoform of the NCOA7 oxidation resistance gene by interferon ß-1b.
Academic Article	Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.
Academic Article	Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis.
Academic Article	Aberrant Type I Interferon Regulation in Autoimmunity: Opposite Directions in MS and SLE, Shaped by Evolution and Body Ecology.
Academic Article	Severe early bilateral macular edema following fingolimod therapy.
Academic Article	Short-term and long-term safety and tolerability of interferon ß-1b in multiple sclerosis.
Academic Article	Validity of the Neurology Quality-of-Life (Neuro-QoL) measurement system in adult epilepsy.
Academic Article	Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial.
Academic Article	First-dose effects of fingolimod: Pooled safety data from three phase 3 studies.
Academic Article	Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial.
Academic Article	Patient Preferences for Injectable Treatments for Multiple Sclerosis in the United States: A Discrete-Choice Experiment.
Academic Article	The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis.
Academic Article	Relapses in multiple sclerosis: Relationship to disability.
Academic Article	Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature.
Academic Article	Corrigendum to 'Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature' [Mult. Scler. Relat. Disord. 9 (2016) 158-162].
Academic Article	Eicosenoids Modify Experimental Allergic Encephalomyelitis.
Academic Article	Vitamin D and Multiple Sclerosis: A Comprehensive Review.
Academic Article	Predictive validity of NEDA in the 16- and 21-year follow-up from the pivotal trial of interferon beta-1b.
Academic Article	Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy.
Academic Article	Early MRI results and odds of attaining 'no evidence of disease activity' status in MS patients treated with interferon ß-1a in the EVIDENCE study.
Academic Article	Gray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.
Academic Article	Dimethyl fumarate-induced changes in the MS lymphocyte repertoire: No need for subset monitoring.
Academic Article	Vitamin D enhances responses to interferon-ß in MS.
Academic Article	Interferon-ß corrects massive gene dysregulation in multiple sclerosis: Short-term and long-term effects on immune regulation and neuroprotection.
Academic Article	Thoracic flexion provokes circumferential dysesthesia: A symptom of thoracic cord lesions in MS.
Academic Article	The rhythms of AMBEs (arousal-related motor behavioral episodes) in Agrypnia Excitata: a video motor analysis.
Academic Article	Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy.
Academic Article	Disability improvement as a clinically relevant outcome in clinical trials of relapsing forms of multiple sclerosis.
Academic Article	COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
Academic Article	Anti-CD20 therapy corrects a CD8 regulatory T cell deficit in multiple sclerosis.
Academic Article	Real-world propensity score comparison of treatment effectiveness of peginterferon beta-1a vs. subcutaneous interferon beta-1a, glatiramer acetate, and teriflunomide in patients with relapsing-remitting multiple sclerosis.
Academic Article	Interferons and Multiple Sclerosis: Lessons from 25 Years of Clinical and Real-World Experience with Intramuscular Interferon Beta-1a (Avonex).
Academic Article	Ocrelizumab treatment for relapsing-remitting multiple sclerosis after a suboptimal response to previous disease-modifying therapy: A nonrandomized controlled trial.
Academic Article	Medications for Multiple Sclerosis and Risk of Malignancy: What Next?
Academic Article	Proposal of new diagnostic criteria for fatal familial insomnia.
Academic Article	Increased Percentage of CD8+CD28- Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis.
Academic Article	T cell responses to COVID-19 infection and vaccination in patients with multiple sclerosis receiving disease-modifying therapy.
Academic Article	Effectiveness of ocrelizumab on clinical and MRI outcome measures in multiple sclerosis across black and white cohorts: A single-center retrospective study.
Academic Article	Prolonged Interferon-Stimulated Gene and Protein Signatures in Multiple Sclerosis Induced by PEGylated IFN-ß-1a Compared to Non-PEGylated IFN-ß-1a.
Academic Article	Effectiveness of rituximab versus oral immunosuppressive therapies in neuromyelitis optica spectrum disorder in a racially diverse cohort of subjects: A single-center retrospective study.
Academic Article	Adaptive and innate immune responses in multiple sclerosis with anti-CD20 therapy: Gene expression and protein profiles.
Academic Article	Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models.
Academic Article	Demographics and baseline disease characteristics of Black and Hispanic patients with multiple sclerosis in the open-label, single-arm, multicenter, phase IV CHIMES trial.
Academic Article	Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients.
Academic Article	Corrigendum: Adaptive and innate immune responses in multiple sclerosis with anti-CD20 therapy: gene expression and protein profiles.
Academic Article	Twenty Years of Subcutaneous Interferon-Beta-1a for Multiple Sclerosis: Contemporary Perspectives.
Academic Article	Novel biomarkers and interferon signature in secondary progressive multiple sclerosis.
Academic Article	Alternative Splicing of RNA Is Excessive in Multiple Sclerosis and Not Linked to Gene Expression Levels: Dysregulation Is Corrected by IFN-ß.
Academic Article	Congenital absence of touch does not preclude normal cognitive and socioemotional development.

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