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Chang, Eugene

One or more keywords matched the following properties of Chang, Eugene

Property	Value
keywords	Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism
overview	Dr. Chang leads a research group focused on studying intestinal microbes and their interactions with the host. This relationship is fundamental to human health, and its disruption can have profound consequences. Dr. Chang’s work explores how environmental and lifestyle changes over the past century may have altered the human microbiome, contributing to the rise of “new age” disorders such as diabetes, obesity, metabolic syndrome, cancer, and autoimmune diseases. In genetically susceptible individuals, these shifts can disrupt immune and metabolic homeostasis, potentially triggering the onset of disease. The Chang Lab is dedicated to understanding the factors that influence the selection and assembly of intestinal microbial communities, with the goal of harnessing this knowledge to reshape the enteric microbiome for disease prevention and treatment. The team employs cutting-edge approaches, including cultivation-dependent and -independent microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional profiling, and advanced bioinformatics to investigate both the host and the microbiome. For more information, visit the laboratory website: http://changlab.uchicago.edu/

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keywords

Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism

overview

Dr. Chang leads a research group focused on studying intestinal microbes and their interactions with the host. This relationship is fundamental to human health, and its disruption can have profound consequences. Dr. Chang’s work explores how environmental and lifestyle changes over the past century may have altered the human microbiome, contributing to the rise of “new age” disorders such as diabetes, obesity, metabolic syndrome, cancer, and autoimmune diseases. In genetically susceptible individuals, these shifts can disrupt immune and metabolic homeostasis, potentially triggering the onset of disease. The Chang Lab is dedicated to understanding the factors that influence the selection and assembly of intestinal microbial communities, with the goal of harnessing this knowledge to reshape the enteric microbiome for disease prevention and treatment. The team employs cutting-edge approaches, including cultivation-dependent and -independent microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional profiling, and advanced bioinformatics to investigate both the host and the microbiome. For more information, visit the laboratory website: http://changlab.uchicago.edu/

One or more keywords matched the following items that are connected to Chang, Eugene

Item Type	Name
Concept	Acute Disease
Concept	Celiac Disease
Concept	Gastrointestinal Diseases
Concept	Cardiovascular Diseases
Concept	Graft vs Host Disease
Concept	Colonic Diseases
Concept	Crohn Disease
Concept	Chronic Disease
Concept	Macular Degeneration
Concept	Digestive System Diseases
Concept	Disease Susceptibility
Concept	Heart Diseases
Concept	Immune System Diseases
Concept	Intestinal Diseases
Concept	Metabolic Diseases
Concept	Pituitary Diseases
Concept	Retinal Diseases
Concept	Inflammatory Bowel Diseases
Concept	Disease Progression
Concept	Asymptomatic Diseases
Concept	Peripheral Arterial Disease
Concept	Alzheimer Disease
Concept	Disease Models, Animal
Concept	Liver Diseases
Concept	Pancreatic Diseases
Concept	Genetic Predisposition to Disease
Concept	Wet Macular Degeneration
Academic Article	Intestinal water and electrolyte absorption and secretion.
Academic Article	Epithelial secretory response to inflammation.
Academic Article	Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia.
Academic Article	Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article	Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure.
Academic Article	Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article	Therapy Insight: gastrointestinal complications of diabetes--pathophysiology and management.
Academic Article	The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review.
Academic Article	Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.
Academic Article	Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article	Role and regulation of intestinal epithelial heat shock proteins in health and disease.
Academic Article	Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.
Academic Article	Cytokine regulation of OCTN2 expression and activity in small and large intestine.
Academic Article	Intestinal electrolyte transport and diarrheal disease (1).
Academic Article	Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Academic Article	miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article	American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article	A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology.
Academic Article	Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article	Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward.
Academic Article	Treatment of diabetic diarrhea with clonidine.
Academic Article	Intestinal electrolyte transport and diarrheal disease (2)
Academic Article	Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Academic Article	Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases.
Academic Article	Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study.
Academic Article	Mechanisms and treatment of diarrhea in inflammatory bowel diseases.
Academic Article	Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Academic Article	Fresh perspectives in chronic constipation and other functional bowel disorders.
Academic Article	Functional predictions from inference and observation in sequence-based inflammatory bowel disease research.
Academic Article	Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Academic Article	Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article	Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article	Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Academic Article	The microbial basis of inflammatory bowel diseases.
Academic Article	Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?
Academic Article	Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article	Exploring gut microbes in human health and disease: Pushing the envelope.
Academic Article	Michael Field, MD (1933-2014).
Academic Article	The role of diet in triggering human inflammatory disorders in the modern age.
Academic Article	Nutrition, microbiomes, and intestinal inflammation.
Academic Article	Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases.
Award or Honor Receipt	National Diabetes and Digestive and Kidney Disease Advisory Council
Academic Article	Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.
Academic Article	IBD and the gut microbiota--from bench to personalized medicine.
Academic Article	Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article	Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article	Neuroprotective interventions: is it too late?
Academic Article	Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article	Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article	Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
Academic Article	Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article	Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article	Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells.
Academic Article	Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article	Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model.
Academic Article	Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor.
Academic Article	Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article	Androgen receptor (AR) in cardiovascular diseases.
Academic Article	New insights into the pathogenesis of cystic fibrosis sinusitis.
Academic Article	Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Academic Article	Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article	Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article	Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article	Precision Genomic Medicine in Cystic Fibrosis.
Academic Article	Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Academic Article	Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.
Academic Article	The gut microbiota and inflammatory bowel diseases.
Academic Article	Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article	Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Academic Article	Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.
Academic Article	O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice.
Academic Article	Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article	Kinase-SUMO networks in diabetes-mediated cardiovascular disease.
Academic Article	Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article	Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.
Academic Article	Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article	Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article	Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article	The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article	Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.
Academic Article	Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article	Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article	Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article	Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Academic Article	Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Academic Article	Regional Diversity of the Gastrointestinal Microbiome.
Academic Article	TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article	Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article	Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article	Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article	Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article	Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article	The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine.
Academic Article	Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes.
Academic Article	Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article	Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Academic Article	Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.
Academic Article	High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article	The Gut Microbiome and Inflammatory Bowel Diseases.
Academic Article	KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.
Academic Article	Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.
Academic Article	High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
Academic Article	Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Academic Article	Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Concept	Non-alcoholic Fatty Liver Disease
Grant	Diet induced obesity from gut microbial disruption of host metabolic networks
Academic Article	Novel role of surfactant protein A in bacterial sinusitis.
Academic Article	Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery.
Academic Article	Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis.
Academic Article	Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Academic Article	Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism.
Academic Article	Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease.
Academic Article	Pregnancy Outcomes of Nifedipine Compared With Labetalol for Oral Treatment of Mild Chronic Hypertension.
Academic Article	Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension.
Academic Article	A Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J Pouch in Patients With Inflammatory Bowel Disease.
Academic Article	Noninvasive, microbiome-based diagnosis of inflammatory bowel disease.
Academic Article	Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease.
Academic Article	Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Grant	Short Term Training: Health Professional Students
Grant	Mutualistic relationship between Hsp25/27 and gut microbes as a major and essential determinant of mucosal healing and microbial fitness following intestinal injury
Grant	CYTOSOLIC CALCIUM &THE REGULATION OF GUT ION TRANSPORT
Grant	Technologies for the discovery of novel human colonic mucosal-associated microbes
Grant	Role and Regulation of Intestinal Na/H Exchanger
Grant	Dietary fat effects on gut microbes, host immune state and experimental colitis
Grant	A cross-sectional and longitudinal study of gut microbiota in Parkinson's disease
Grant	The Role of the Gut Microbiota in Ulcerative Colitis
Grant	Digestive Health and Diseases (DHD) Training Grant
Grant	The Role of the Gut Microbiota in Ulcerative Colitis
Grant	Cytoprotective Role of Heat Shock Proteins in IBD
Grant	ADRENERGIC CONTROL OF GUT SECRETION AND ROLE IN DIARRHEA
Academic Article	Mulberry Fruit Extract Promotes Serum HDL-Cholesterol Levels and Suppresses Hepatic microRNA-33 Expression in Rats Fed High Cholesterol/Cholic Acid Diet.
Academic Article	Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy.
Academic Article	Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery.
Academic Article	Fecal Microbial Profiles and Short-Chain Fatty Acid/Bile Acid Metabolomics in Patients With Age-Related Macular Degeneration: A Pilot Study.

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