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One or more keywords matched the following properties of Chang, Eugene B.
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keywords Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism
overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
One or more keywords matched the following items that are connected to Chang, Eugene B.
Item TypeName
Academic Article Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon.
Academic Article 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.
Academic Article Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon.
Academic Article Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward.
Academic Article Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community.
Academic Article The microbial basis of inflammatory bowel diseases.
Academic Article Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects.
Academic Article Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?
Academic Article Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa.
Academic Article Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis.
Academic Article Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Nutrition, microbiomes, and intestinal inflammation.
Academic Article Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases.
Academic Article The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.
Academic Article IBD and the gut microbiota--from bench to personalized medicine.
Academic Article Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice.
Academic Article Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K.
Academic Article Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article Transplanting a Microbial Organ: the Good, the Bad, and the Unknown.
Academic Article A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.
Academic Article Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.
Academic Article The gut microbiota and inflammatory bowel diseases.
Academic Article Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article The Gut Microbiota: The Gateway to Improved Metabolism.
Academic Article Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.
Academic Article Patient-Specific Bacteroides Genome Variants in Pouchitis.
Academic Article Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Academic Article Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.
Academic Article Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade.
Academic Article Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.
Academic Article Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.
Academic Article Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Academic Article The Human Microbiome and Obesity: Moving beyond Associations.
Academic Article Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).
Academic Article Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts.
Academic Article Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.
Academic Article Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article Responsible stewardship for communicating microbiome research to the press and public.
Academic Article Regional Diversity of the Gastrointestinal Microbiome.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.
Academic Article TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
Academic Article Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
Academic Article Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article IBD Microbial Metabolome: The Good, Bad, and Unknown.
Academic Article Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine.
Academic Article The microbiome: Composition and locations.
Academic Article Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article The Gut Microbiome and Inflammatory Bowel Diseases.
Academic Article Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction.
Academic Article High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
Academic Article Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome.
Academic Article Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Academic Article Gut microbiota modulates bleomycin-induced acute lung injury response in mice.
Academic Article Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Concept Gastrointestinal Microbiome
Concept Fecal Microbiota Transplantation
Concept Microbiota
Academic Article Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity.
Academic Article Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.
Academic Article Gut microbes and the liver circadian clock partition glucose and lipid metabolism.
Academic Article Microbiota-dependent early life programming of gastrointestinal motility.
Academic Article The Host-specific Microbiota is Required for Diet-Specific Metabolic Homeostasis.
Academic Article Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
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  • Microbiome