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Chang, Eugene B.

One or more keywords matched the following properties of Chang, Eugene B.

Property	Value
keywords	Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism
overview	The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/

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Value

keywords

Microbiome, inflammation, mucosal immunity, inflammatory bowel diseases, metabolism

overview

The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/

One or more keywords matched the following items that are connected to Chang, Eugene B.

Item Type	Name
Concept	Energy Metabolism
Concept	Inflammation
Concept	Inflammatory Bowel Diseases
Concept	Inflammation Mediators
Concept	Immunity, Mucosal
Concept	Lipid Metabolism
Academic Article	Epithelial secretory response to inflammation.
Academic Article	T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Academic Article	Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure.
Academic Article	Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article	Phorbol ester-stimulated secretion in chicken ileum: role of arachidonic acid metabolism.
Academic Article	Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon.
Academic Article	16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.
Academic Article	Standard colonic lavage alters the natural state of mucosal-associated microbiota in the human colon.
Academic Article	Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Academic Article	miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
Academic Article	American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article	The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen.
Academic Article	Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Academic Article	Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article	Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Academic Article	Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection.
Academic Article	Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article	The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away.
Academic Article	Do heat shock proteins play any role in gut inflammation?
Academic Article	Studying the Enteric Microbiome in Inflammatory Bowel Diseases: Getting through the Growing Pains and Moving Forward.
Academic Article	Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Academic Article	Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity.
Academic Article	Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases.
Academic Article	Mechanisms and treatment of diarrhea in inflammatory bowel diseases.
Academic Article	Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Academic Article	Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Academic Article	Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article	Functional predictions from inference and observation in sequence-based inflammatory bowel disease research.
Academic Article	Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article	Bacterial community structure and functional contributions to emergence of health or necrotizing enterocolitis in preterm infants.
Academic Article	Commensal bacteria protect against food allergen sensitization.
Academic Article	Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article	A gene-targeted approach to investigate the intestinal butyrate-producing bacterial community.
Academic Article	The microbial basis of inflammatory bowel diseases.
Academic Article	Comparison of brush and biopsy sampling methods of the ileal pouch for assessment of mucosa-associated microbiota of human subjects.
Academic Article	Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Academic Article	Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?
Academic Article	Gene-targeted microfluidic cultivation validated by isolation of a gut bacterium listed in Human Microbiome Project's Most Wanted taxa.
Academic Article	Multiphasic analysis of the temporal development of the distal gut microbiota in patients following ileal pouch anal anastomosis.
Academic Article	Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article	The role of diet in triggering human inflammatory disorders in the modern age.
Academic Article	Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article	Nutrition, microbiomes, and intestinal inflammation.
Academic Article	Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases.
Academic Article	The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013.
Academic Article	Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.
Academic Article	IBD and the gut microbiota--from bench to personalized medicine.
Academic Article	Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article	Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article	Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article	Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article	Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article	Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article	Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice.
Academic Article	Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article	Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article	Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model.
Academic Article	Daikenchuto (TU-100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K.
Academic Article	Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition.
Academic Article	Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article	Transplanting a Microbial Organ: the Good, the Bad, and the Unknown.
Academic Article	A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice.
Academic Article	Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article	Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article	Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article	Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article	Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Academic Article	Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota.
Academic Article	Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.
Academic Article	The gut microbiota and inflammatory bowel diseases.
Academic Article	Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article	The Gut Microbiota: The Gateway to Improved Metabolism.
Academic Article	Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.
Academic Article	Patient-Specific Bacteroides Genome Variants in Pouchitis.
Academic Article	Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Academic Article	Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.
Academic Article	O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice.
Academic Article	Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article	Kinase-SUMO networks in diabetes-mediated cardiovascular disease.
Academic Article	Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article	Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.
Academic Article	Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article	A new role for microbiota? Dulling the thrust of serotonin and 5-HT3 signaling cascade.
Academic Article	Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.
Academic Article	Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article	Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.
Academic Article	Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article	Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.
Academic Article	Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article	Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article	Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.
Academic Article	Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article	The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article	Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Academic Article	The Human Microbiome and Obesity: Moving beyond Associations.
Academic Article	Time-, Sex-, and Dose-Dependent Alterations of the Gut Microbiota by Consumption of Dietary Daikenchuto (TU-100).
Academic Article	Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts.
Academic Article	Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice.
Academic Article	Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.
Academic Article	Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation: Current Status and Future Directions.
Academic Article	Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article	Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article	Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article	Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article	Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article	Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats.
Academic Article	Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Academic Article	Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Academic Article	Responsible stewardship for communicating microbiome research to the press and public.
Academic Article	Regional Diversity of the Gastrointestinal Microbiome.
Academic Article	Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury.
Academic Article	Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article	Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.
Academic Article	TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article	Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
Academic Article	Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article	Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
Academic Article	Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article	IBD Microbial Metabolome: The Good, Bad, and Unknown.
Academic Article	Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes.
Academic Article	Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article	Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article	Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article	Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article	The Gut Microbiome: Reaching the Promise Through Discovery- Advancing Knowledge and Discovery of the Gut Microbiome in the Age of Precision Medicine.
Academic Article	Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes.
Academic Article	The microbiome: Composition and locations.
Academic Article	Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Academic Article	Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article	Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Academic Article	High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article	The Gut Microbiome and Inflammatory Bowel Diseases.
Academic Article	Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats.
Academic Article	Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article	Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.
Academic Article	High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction.
Academic Article	High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
Academic Article	Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome.
Academic Article	Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Academic Article	Gut microbiota modulates bleomycin-induced acute lung injury response in mice.
Academic Article	Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet.
Academic Article	Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Concept	Gastrointestinal Microbiome
Concept	Fecal Microbiota Transplantation
Concept	Microbiota
Academic Article	Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity.

Search Criteria

Microbiome
inflammation
mucosal immunity
inflammatory bowel diseases
metabolism