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Search Results to Eugene B. Chang

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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/

One or more keywords matched the following items that are connected to Chang, Eugene B.

Item TypeName
Concept Models, Molecular
Concept Models, Cardiovascular
Concept Models, Animal
Concept Disease Models, Animal
Concept Models, Biological
Academic Article Intestinal water and electrolyte absorption and secretion.
Academic Article Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport.
Academic Article Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia.
Academic Article Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.
Academic Article Utilization of the delay phenomenon improves blood flow and reduces collagen deposition in esophagogastric anastomoses.
Academic Article The pharmacological modification of secretory responses.
Academic Article Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Academic Article Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.
Academic Article Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis.
Academic Article Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model.
Academic Article Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Academic Article Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology.
Academic Article Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away.
Academic Article Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
Academic Article Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Academic Article Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Academic Article Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected].
Academic Article Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.
Academic Article Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC).
Academic Article Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model.
Academic Article Neuroprotective interventions: is it too late?
Academic Article Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
Academic Article Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article Novel role of kallistatin in vascular repair by promoting mobility, viability, and function of endothelial progenitor cells.
Academic Article Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
Academic Article Depot-Specific Changes in Fat Metabolism with Aging in a Type 2 Diabetic Animal Model.
Academic Article New insights into the pathogenesis of cystic fibrosis sinusitis.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Academic Article Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.
Academic Article Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article Kinase-SUMO networks in diabetes-mediated cardiovascular disease.
Academic Article Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome.
Academic Article Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.
Academic Article Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article The Human Microbiome and Obesity: Moving beyond Associations.
Academic Article Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.
Academic Article Considerations for best practices in studies of fiber or other dietary components and the intestinal microbiome.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Academic Article Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article Development and Validation of a Risk Model for Breast Cancer-Related Lymphedema.
Academic Article Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.
Academic Article KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.

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