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One or more keywords matched the following properties of Chang, Eugene B.
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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
One or more keywords matched the following items that are connected to Chang, Eugene B.
Item TypeName
Concept Mice, Inbred Strains
Concept Mice, Transgenic
Concept Mice, Inbred BALB C
Concept Mice, Inbred C57BL
Concept Mice, Obese
Concept Mice, Knockout
Concept Mice
Concept Mice, Inbred CFTR
Concept Mice, Mutant Strains
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa.
Academic Article Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation.
Academic Article Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress.
Academic Article Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic.
Academic Article T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase.
Academic Article High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa.
Academic Article Bacterial superantigen-treated intestinal epithelial cells upregulate heat shock proteins 25 and 72 and are resistant to oxidant cytotoxicity.
Academic Article Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
Academic Article Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells.
Academic Article AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins.
Academic Article Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells.
Academic Article Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Academic Article This month in gastroenterology.
Academic Article Tumor necrosis factor-alpha and interferon-gamma increase PepT1 expression and activity in the human colon carcinoma cell line Caco-2/bbe and in mouse intestine.
Academic Article Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium.
Academic Article Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.
Academic Article Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa.
Academic Article Escherichia coli LPS induces heat shock protein 25 in intestinal epithelial cells through MAP kinase activation.
Academic Article Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Academic Article Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Academic Article Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.
Academic Article Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa.
Academic Article Heat induction of heat shock protein 25 requires cellular glutamine in intestinal epithelial cells.
Academic Article Cytokine regulation of OCTN2 expression and activity in small and large intestine.
Academic Article Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin.
Academic Article Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon.
Academic Article Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
Academic Article Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model.
Academic Article Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
Academic Article Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer.
Academic Article Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Academic Article Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Academic Article Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Academic Article Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Academic Article Competence and sporulation factor derived from Bacillus subtilis improves epithelial cell injury in intestinal inflammation via immunomodulation and cytoprotection.
Academic Article Translational inhibition of colonic epithelial heat shock proteins by IFN-gamma and TNF-alpha in intestinal inflammation.
Academic Article PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation.
Academic Article The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis.
Academic Article Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells.
Academic Article Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.
Academic Article Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity.
Academic Article Requirements for ion and solute transport, and pH regulation during enamel maturation.
Academic Article Targeting vaccinia to solid tumors with local hyperthermia.
Academic Article p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Academic Article Parathyroid hormone suppresses insulin signaling in adipocytes.
Academic Article 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes.
Academic Article Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.
Academic Article A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Academic Article Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Academic Article Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.
Academic Article TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.
Academic Article Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.
Academic Article Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.
Academic Article Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Academic Article Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases.
Academic Article Sirt1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation.
Academic Article Intracellular HMGB1: defender of client proteins and cell fate.
Academic Article Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Academic Article Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Academic Article N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model.
Academic Article Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis.
Academic Article Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Adiponectin deletion impairs insulin signaling in insulin-sensitive but not insulin-resistant 3T3-L1 adipocytes.
Academic Article Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1a and transforming growth factor-ß1 expression.
Academic Article Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice.
Academic Article Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.
Academic Article Restoration of adiponectin expression via the ERK pathway in TNFa-treated 3T3-L1 adipocytes.
Academic Article Ezetimibe stimulates intestinal glucagon-like peptide 1 secretion via the MEK/ERK pathway rather than dipeptidyl peptidase 4 inhibition.
Academic Article Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice.
Academic Article Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.
Academic Article Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.
Academic Article Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells.
Academic Article Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer.
Academic Article Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Academic Article Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice.
Academic Article Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis.
Academic Article O-014 Bacterial Sensor NOD2 Deletion Causes Th2-Inflammatory Bowel Disease Improvement Without Inducing Acute Metatranscriptomic Dysbiosis in Mice.
Academic Article Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models.
Academic Article Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes.
Academic Article Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway.
Academic Article Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring.
Academic Article Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.
Academic Article Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.
Academic Article Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2.
Academic Article Distinct roles of intracellular heat shock protein 70 in maintaining gastrointestinal homeostasis.
Academic Article Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Academic Article Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis.
Academic Article Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article Microbiome characterization by high-throughput transfer RNA sequencing and modification analysis.
Academic Article Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy.
Academic Article Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR).
Academic Article Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Academic Article Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
Academic Article Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article Vitamin D Ameliorates Fat Accumulation with AMPK/SIRT1 Activity in C2C12 Skeletal Muscle Cells.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine Model.
Academic Article Inflammatory Bowel Diseases (IBD) and the Microbiome-Searching the Crime Scene for Clues.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.
Academic Article High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Academic Article A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Academic Article KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.
Academic Article Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
Academic Article Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome.
Academic Article Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Academic Article Gut microbiota modulates bleomycin-induced acute lung injury response in mice.
Academic Article Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet.
Academic Article Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Academic Article Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells.
Academic Article Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity.
Academic Article Novel role of surfactant protein A in bacterial sinusitis.
Academic Article Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization.
Academic Article Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery.
Academic Article Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Academic Article Gut microbes and the liver circadian clock partition glucose and lipid metabolism.
Academic Article Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis.
Academic Article Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Academic Article Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism.
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