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Search Results to Eugene B. Chang

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One or more keywords matched the following properties of Chang, Eugene

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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/

One or more keywords matched the following items that are connected to Chang, Eugene

Item TypeName
Concept Obesity
Concept Obesity, Morbid
Concept Anti-Obesity Agents
Academic Article Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Academic Article Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Academic Article A model for gastric banding in the treatment of morbid obesity: the effect of chronic partial gastric outlet obstruction on esophageal physiology.
Academic Article Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity.
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.
Academic Article Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice.
Academic Article Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats.
Academic Article The Gut Microbiota: The Gateway to Improved Metabolism.
Academic Article Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article Vitamin D Insufficiency Exacerbates Adipose Tissue Macrophage Infiltration and Decreases AMPK/SIRT1 Activity in Obese Rats.
Academic Article The Human Microbiome and Obesity: Moving beyond Associations.
Academic Article Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats.
Academic Article Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR).

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  • Obesity