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overview
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Dr. Chang leads a research group focused on studying intestinal microbes and their interactions with the host. This relationship is fundamental to human health, and its disruption can have profound consequences. Dr. Chang’s work explores how environmental and lifestyle changes over the past century may have altered the human microbiome, contributing to the rise of “new age” disorders such as diabetes, obesity, metabolic syndrome, cancer, and autoimmune diseases. In genetically susceptible individuals, these shifts can disrupt immune and metabolic homeostasis, potentially triggering the onset of disease.
The Chang Lab is dedicated to understanding the factors that influence the selection and assembly of intestinal microbial communities, with the goal of harnessing this knowledge to reshape the enteric microbiome for disease prevention and treatment. The team employs cutting-edge approaches, including cultivation-dependent and -independent microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional profiling, and advanced bioinformatics to investigate both the host and the microbiome.
For more information, visit the laboratory website: http://changlab.uchicago.edu/
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