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Search Results to Eugene B. Chang

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One or more keywords matched the following properties of Chang, Eugene B.

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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/

One or more keywords matched the following items that are connected to Chang, Eugene B.

Item TypeName
Concept Biological Evolution
Concept Colony Count, Microbial
Concept Microbial Viability
Academic Article Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon.
Academic Article The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article The microbial basis of inflammatory bowel diseases.
Academic Article Transplanting a Microbial Organ: the Good, the Bad, and the Unknown.
Academic Article Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Soluble bioactive microbial mediators regulate proteasomal degradation and autophagy to protect against inflammation-induced stress.
Academic Article Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article Microbial metabolites in health and disease: Navigating the unknown in search of function.
Academic Article Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
Academic Article Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility.
Academic Article The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Regional Diversity of the Gastrointestinal Microbiome.
Academic Article Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Academic Article Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article IBD Microbial Metabolome: The Good, Bad, and Unknown.
Academic Article Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Academic Article Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Academic Article High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction.

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  • evolution