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One or more keywords matched the following properties of Chang, Eugene B.
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overview The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome. For more information, visit my laboratory website: http://changlab.uchicago.edu/
One or more keywords matched the following items that are connected to Chang, Eugene B.
Item TypeName
Concept Vaccinia virus
Concept Virus Inactivation
Concept Viruses
Concept Receptors, Virus
Academic Article 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis.
Academic Article Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function.
Academic Article American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.
Academic Article The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen.
Academic Article Lymphotoxin regulates commensal responses to enable diet-induced obesity.
Academic Article Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases.
Academic Article Targeting vaccinia to solid tumors with local hyperthermia.
Academic Article Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article Diet-induced expansion of pathobionts in experimental colitis: implications for tailored therapies.
Academic Article Commensal bacteria protect against food allergen sensitization.
Academic Article Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?
Academic Article Exploring gut microbes in human health and disease: Pushing the envelope.
Academic Article The role of diet in triggering human inflammatory disorders in the modern age.
Academic Article Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.
Academic Article Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Dead or alive: Deoxyribonuclease I sensitive bacteria and implications for the sinus microbiome.
Academic Article Divergent responses of viral and bacterial communities in the gut microbiome to dietary disturbances in mice.
Academic Article Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Academic Article Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.
Academic Article Evolutionary and ecological forces that shape the bacterial communities of the human gut.
Academic Article Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption.
Academic Article The intestinal microbiota in the pathogenesis of inflammatory bowel diseases: new insights into complex disease.
Academic Article Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes.
Academic Article Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.
Academic Article Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Academic Article Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes.
Academic Article Microbe-Derived Butyrate and Its Receptor, Free Fatty Acid Receptor 3, But Not Free Fatty Acid Receptor 2, Mitigate Neointimal Hyperplasia Susceptibility After Arterial Injury.
Academic Article Navigating the Human Gut Microbiome: Pathway to Success from Lessons Learned.
Academic Article A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Academic Article The regulatory role of N6 -methyladenosine modification in the interaction between host and microbes.
Academic Article Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity.
Academic Article Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Academic Article Gut microbes and the liver circadian clock partition glucose and lipid metabolism.
Academic Article A cryptic plasmid is among the most numerous genetic elements in the human gut.
Search Criteria
  • viruses
  • bacteria
  • commensal
  • microbes