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Search Results to Jean Greenberg

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One or more keywords matched the following properties of Greenberg, Jean

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overview Research My broad interest is in how organisms adapt to a changing environment. My lab studies this in the context of pathogen-host interactions using the gram negative pathogen Pseudomonas syringae and its interaction with several plants: the non-crop models Arabidopsis thaliana and Nicotiana benthamiana, and the crop plants tomato and snap beans. In response to infection, plants mount a complex local defense response involving cell suicide, changes at the plasma membrane, the crosslinking of cell wall components, production of antimicrobials and defense gene activation. Some leaf infections induce a primed state that allows plants to respond faster when a second infection occurs on distal leaves (systemic acquired resistance, SAR). Interactions of roots with beneficial microbes also induces a primed state in the aerial part of the plant (and induced systemic resistance, ISR). Although SAR and ISR were considered different immune programs, we have found that some of the same are proteins required for both systemic programs. These proteins are involved in mobilizing small molecule signals. The lab investigates plant defense and pathogen virulence mechanisms. We study how plants regulate their responses to pathogens by (1) using plant mutants that express one or more aspects of the defense response in the absence of pathogens or are compromised for local defense activation or SAR, (2) discovering and tracking the production and movement of novel defense signals and pathogen-derived molecules, and (3) exploiting secreted virulence effector proteins from the pathogen to discover immune components and discern how they are modified. This involves combining genetic analysis (including mosaic plants in which only some cells/tissues express specific defense components) with biochemistry and cell biology. We are very interested in how the defense response is coordinated and towards this end, we are investigating the sites of action at the tissue and subcellular levels of key SAR/ISR proteins. On the pathogen side, we are also characterizing how P. syringae uses its type III secretion apparatus and secreted effectors to modulate immunity and colonize plant tissue, including the surfaces of a leaf, a unique niche. We are using proteomic approaches to discern how pathogen effectors post-translationally modify both other pathogen effectors and host immune complexes to suppress signaling. We are interested in exploiting what we learn about P. syringae effectors to study orthologous effectors from diverse pathogens of both plants and animals. Our lab welcomes participants from all over the world and at many levels of education (highschool, college, predoctoral, postdoctoral and teachers). Professional Activities and Service I am a Senior Editor of The Plant Cell, a Reviewing Editor of eLIFE and Secretary to the Board of Directors of the International Society of Plant-Microbe Interactions. I am a member of the American Society of Plant Biology and the Society for Experimental Biology. I participated in developing and writing a recently published white paper concerning the promotion of plant heath: "Foundational and translational research opportunities to improve plant health." I am a strong advocate for diversity in science and serve on the University of Chicago Division of Biology's Diversity Committee and on the steering committee of the Molecular Genetics and Cell Biology Department's National Science Foundation-sponsored Research Education for Undergraduates program.

One or more keywords matched the following items that are connected to Greenberg, Jean

Item TypeName
Concept Intracellular Signaling Peptides and Proteins
Concept Signal Transduction
Academic Article The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth.
Academic Article A role for salicylic acid and NPR1 in regulating cell growth in Arabidopsis.
Academic Article ACD6, a novel ankyrin protein, is a regulator and an effector of salicylic acid signaling in the Arabidopsis defense response.
Academic Article A key role for ALD1 in activation of local and systemic defenses in Arabidopsis.
Academic Article Degrade or die: a dual function for autophagy in the plant immune response.
Academic Article Structure-function analysis of the plasma membrane- localized Arabidopsis defense component ACD6.
Academic Article Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants.
Academic Article A key role for the Arabidopsis WIN3 protein in disease resistance triggered by Pseudomonas syringae that secrete AvrRpt2.
Academic Article SGT1b is required for HopZ3-mediated suppression of the epiphytic growth of Pseudomonas syringae on N. benthamiana.
Academic Article Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1.
Academic Article Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis.
Academic Article A J domain virulence effector of Pseudomonas syringae remodels host chloroplasts and suppresses defenses.
Academic Article Priming in systemic plant immunity.
Academic Article Salicylic acid regulates Arabidopsis microbial pattern receptor kinase levels and signaling.
Academic Article Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6.
Academic Article Arabidopsis AZI1 family proteins mediate signal mobilization for systemic defence priming.
Academic Article Linking pattern recognition and salicylic acid responses in Arabidopsis through ACCELERATED CELL DEATH6 and receptors.
Academic Article Editorial: Salicylic Acid Signaling Networks.
Grant Post-translational Modifications as Modulators of Crop Plant Defense Signaling: a Systems Approach
Grant Defense amplification and priming in Arabidopsis

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