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One or more keywords matched the following properties of Greenberg, Jean

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keywords systemic acquired resistance
keywords induced systemic resistance
overview Research My broad interest is in how organisms adapt to a changing environment. My lab studies this in the context of pathogen-host interactions using the gram negative pathogen Pseudomonas syringae and its interaction with several plants: the non-crop models Arabidopsis thaliana and Nicotiana benthamiana, and the crop plants tomato and snap beans. In response to infection, plants mount a complex local defense response involving cell suicide, changes at the plasma membrane, the crosslinking of cell wall components, production of antimicrobials and defense gene activation. Some leaf infections induce a primed state that allows plants to respond faster when a second infection occurs on distal leaves (systemic acquired resistance, SAR). Interactions of roots with beneficial microbes also induces a primed state in the aerial part of the plant (and induced systemic resistance, ISR). Although SAR and ISR were considered different immune programs, we have found that some of the same are proteins required for both systemic programs. These proteins are involved in mobilizing small molecule signals. The lab investigates plant defense and pathogen virulence mechanisms. We study how plants regulate their responses to pathogens by (1) using plant mutants that express one or more aspects of the defense response in the absence of pathogens or are compromised for local defense activation or SAR, (2) discovering and tracking the production and movement of novel defense signals and pathogen-derived molecules, and (3) exploiting secreted virulence effector proteins from the pathogen to discover immune components and discern how they are modified. This involves combining genetic analysis (including mosaic plants in which only some cells/tissues express specific defense components) with biochemistry and cell biology. We are very interested in how the defense response is coordinated and towards this end, we are investigating the sites of action at the tissue and subcellular levels of key SAR/ISR proteins. On the pathogen side, we are also characterizing how P. syringae uses its type III secretion apparatus and secreted effectors to modulate immunity and colonize plant tissue, including the surfaces of a leaf, a unique niche. We are using proteomic approaches to discern how pathogen effectors post-translationally modify both other pathogen effectors and host immune complexes to suppress signaling. We are interested in exploiting what we learn about P. syringae effectors to study orthologous effectors from diverse pathogens of both plants and animals. Our lab welcomes participants from all over the world and at many levels of education (highschool, college, predoctoral, postdoctoral and teachers). Professional Activities and Service I am a Senior Editor of The Plant Cell, a Reviewing Editor of eLIFE and Secretary to the Board of Directors of the International Society of Plant-Microbe Interactions. I am a member of the American Society of Plant Biology and the Society for Experimental Biology. I participated in developing and writing a recently published white paper concerning the promotion of plant heath: "Foundational and translational research opportunities to improve plant health." I am a strong advocate for diversity in science and serve on the University of Chicago Division of Biology's Diversity Committee and on the steering committee of the Molecular Genetics and Cell Biology Department's National Science Foundation-sponsored Research Education for Undergraduates program.

One or more keywords matched the following items that are connected to Greenberg, Jean

Item TypeName
Concept Enzyme Induction
Concept Deoxyribonuclease IV (Phage T4-Induced)
Concept Disease Resistance
Concept Drug Resistance, Microbial
Academic Article Uncoupling salicylic acid-dependent cell death and defense-related responses from disease resistance in the Arabidopsis mutant acd5.
Academic Article Differential expression of a senescence-enhanced metallothionein gene in Arabidopsis in response to isolates of Peronospora parasitica and Pseudomonas syringae.
Academic Article The Arabidopsis aberrant growth and death2 mutant shows resistance to Pseudomonas syringae and reveals a role for NPR1 in suppressing hypersensitive cell death.
Academic Article Positive and negative regulation of salicylic acid-dependent cell death and pathogen resistance in Arabidopsis lsd6 and ssi1 mutants.
Academic Article A key role for ALD1 in activation of local and systemic defenses in Arabidopsis.
Academic Article Signaling pathways that regulate the enhanced disease resistance of Arabidopsis "defense, no death" mutants.
Academic Article A key role for the Arabidopsis WIN3 protein in disease resistance triggered by Pseudomonas syringae that secrete AvrRpt2.
Academic Article SGT1b is required for HopZ3-mediated suppression of the epiphytic growth of Pseudomonas syringae on N. benthamiana.
Academic Article Priming in systemic plant immunity.
Academic Article Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
Academic Article ALD1 Regulates Basal Immune Components and Early Inducible Defense Responses in Arabidopsis.
Academic Article Arabidopsis AZI1 family proteins mediate signal mobilization for systemic defence priming.
Academic Article Linking pattern recognition and salicylic acid responses in Arabidopsis through ACCELERATED CELL DEATH6 and receptors.
Grant Post-translational Modifications as Modulators of Crop Plant Defense Signaling: a Systems Approach
Grant Defense amplification and priming in Arabidopsis
Academic Article Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus.
Academic Article Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation.
Academic Article Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.
Academic Article A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress.
Academic Article Underground Azelaic Acid-Conferred Resistance to Pseudomonas syringae in Arabidopsis.
Academic Article PROHIBITIN3 Forms Complexes with ISOCHORISMATE SYNTHASE1 to Regulate Stress-Induced Salicylic Acid Biosynthesis in Arabidopsis.
Academic Article Kinases and protein motifs required for AZI1 plastid localization and trafficking during plant defense induction.
Academic Article ALD1 accumulation in Arabidopsis epidermal plastids confers local and non-autonomous disease resistance.
Academic Article An Improved Bioassay to Study Arabidopsis Induced Systemic Resistance (ISR) Against Bacterial Pathogens and Insect Pests.

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  • induced
  • systemic
  • resistance