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One or more keywords matched the following properties of Gounari, Fotini
overview Fotini Gounari’s laboratory studies how transcription and epigenetic regulators cooperate to guide T cell development. The role of individual regulators is becoming increasingly clear in the development of T cells. However, much less is known on how these regulatory molecules are integrated into complex networks that drive the chromatin conformation and gene expression changes required at each stage of T-cell development. The objectives of the studies are to elucidate how the DNA-binding protein T-cell factor 1 (Tcf-1), coordinates the action of multiple epigenetic and transcription regulators to control gene expression events that instruct T cell differentiation. The long-term goal is to provide a blueprint of the interplay of molecular networks in the development of healthy T-cell immunity and to understand mechanisms underlying immune-related diseases and T cell malignancies.
One or more keywords matched the following items that are connected to Gounari, Fotini
Item TypeName
Concept Bone Marrow Cells
Concept Antigens, Differentiation, T-Lymphocyte
Concept B-Lymphocytes
Concept Dendritic Cells
Concept Epithelial Cells
Concept Hematopoietic Stem Cells
Concept Mast Cells
Concept HeLa Cells
Concept Hybrid Cells
Concept Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Concept Stem Cells
Concept CHO Cells
Concept Th1 Cells
Concept Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Concept Tumor Cells, Cultured
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept CD4-Positive T-Lymphocytes
Concept Lymphocytes, Tumor-Infiltrating
Concept T-Lymphocyte Subsets
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept CD8-Positive T-Lymphocytes
Concept Natural Killer T-Cells
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Precursor Cells, B-Lymphoid
Concept T-Lymphocytes, Cytotoxic
Concept Leukemia-Lymphoma, Adult T-Cell
Concept Lymphoma, T-Cell
Concept Totipotent Stem Cells
Concept T-Lymphocytes, Regulatory
Concept Lymphoid Progenitor Cells
Concept Th17 Cells
Concept Cells, Cultured
Concept Lymphocytes
Concept Receptors, Antigen, T-Cell
Concept T-Lymphocytes
Concept Myeloid Cells
Academic Article Filensin and phakinin form a novel type of beaded intermediate filaments and coassemble de novo in cultured cells.
Academic Article Contributions of the structural domains of filensin in polymer formation and filament distribution.
Academic Article The activation domain of a hormone inducible HTLV-1 Rex protein determines colocalization with the nuclear pore.
Academic Article EblacZ tumor dormancy in bone marrow and lymph nodes: active control of proliferating tumor cells by CD8+ immune T cells.
Academic Article The extended packaging sequence of MoMLV contains a constitutive mRNA nuclear export function.
Academic Article Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT.
Academic Article Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.
Academic Article On the brink of becoming a T cell.
Academic Article Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Academic Article Thymic selection revisited: how essential is it?
Academic Article A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.
Academic Article Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.
Academic Article Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development.
Academic Article Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.
Academic Article Novel adenomatous polyposis coli gene promoter is located 40 kb upstream of the initiating methionine.
Academic Article Loss of adenomatous polyposis coli gene function disrupts thymic development.
Academic Article Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Academic Article Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction.
Academic Article Mast cells are an essential hematopoietic component for polyp development.
Academic Article Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation.
Academic Article Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.
Academic Article c-Myc mediates pre-TCR-induced proliferation but not developmental progression.
Academic Article T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
Academic Article TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.
Academic Article Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.
Academic Article Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.
Academic Article Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication.
Academic Article Sleeping beauty: does ETP-ALL awaken later?
Academic Article The significant role of mast cells in cancer.
Academic Article Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.
Academic Article The My(c)stery of iNKT cell ontogeny.
Academic Article The TLX1 oncogene drives aneuploidy in T cell transformation.
Academic Article Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation.
Academic Article The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments.
Academic Article A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.
Academic Article Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.
Academic Article Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.
Academic Article T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
Academic Article Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells.
Academic Article Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer.
Academic Article A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.
Academic Article Current status of interleukin-10 and regulatory T-cells in cancer.
Academic Article Transcriptional regulation of the Ikzf1 locus.
Academic Article Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Academic Article ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.
Academic Article ß-Catenin induces T-cell transformation by promoting genomic instability.
Academic Article T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.
Academic Article Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer.
Academic Article Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.
Academic Article The two faces of regulatory T cells in cancer.
Academic Article The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.
Academic Article Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.
Academic Article Chromatin restriction by the nucleosome remodeler Mi-2ß and functional interplay with lineage-specific transcription regulators control B-cell differentiation.
Academic Article CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis.
Academic Article Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer.
Academic Article DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
Academic Article CRELD1 controls T cell homeostasis.
Academic Article Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.
Academic Article TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer.
Academic Article Tcf-1 promotes genomic instability and T cell transformation in response to aberrant ß-catenin activation.
Grant The role of b-catenin/Tcf-1 signaling in T-cell leukemia/lymphoma
Grant Signaling in thymic selection
Grant Wnt/b-catenin signaling in T-cell transformation
Grant How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal
Academic Article Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells.
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  • T Cells