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overview Fotini Gounari’s laboratory studies how transcription and epigenetic regulators cooperate to guide T cell development. The role of individual regulators is becoming increasingly clear in the development of T cells. However, much less is known on how these regulatory molecules are integrated into complex networks that drive the chromatin conformation and gene expression changes required at each stage of T-cell development. The objectives of the studies are to elucidate how the DNA-binding protein T-cell factor 1 (Tcf-1), coordinates the action of multiple epigenetic and transcription regulators to control gene expression events that instruct T cell differentiation. The long-term goal is to provide a blueprint of the interplay of molecular networks in the development of healthy T-cell immunity and to understand mechanisms underlying immune-related diseases and T cell malignancies.

One or more keywords matched the following items that are connected to Gounari, Fotini

Item TypeName
Concept Transcription Factors
Concept Sp1 Transcription Factor
Concept Gene Regulatory Networks
Concept STAT3 Transcription Factor
Concept NFI Transcription Factors
Concept Kruppel-Like Transcription Factors
Concept NFATC Transcription Factors
Concept p300-CBP Transcription Factors
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Ikaros Transcription Factor
Concept T Cell Transcription Factor 1
Concept Forkhead Transcription Factors
Academic Article Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT.
Academic Article Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Academic Article Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction.
Academic Article TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.
Academic Article Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling.
Academic Article Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication.
Academic Article Transcription of the promoter of the rat NF-1 gene depends on the integrity of an Sp1 recognition site.
Academic Article Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.
Academic Article T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.
Academic Article Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA.
Academic Article Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer.
Academic Article A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.
Academic Article Fingerprinting ikaros.
Academic Article Transcriptional regulation of the Ikzf1 locus.
Academic Article Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Academic Article ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.
Academic Article ß-Catenin induces T-cell transformation by promoting genomic instability.
Academic Article Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.
Academic Article The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.
Academic Article TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.
Academic Article Chromatin restriction by the nucleosome remodeler Mi-2ß and functional interplay with lineage-specific transcription regulators control B-cell differentiation.
Academic Article DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.

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  • Transcription Factor
  • Networks